Baker Heart Research Inst.

Aromatase-deficient mice have reduced blood pressure, baroreflex sensitivity

Published in Hospital and Nursing Home Week, October 28th, 2004

According to published research from Australia, "Aromatase-deficient (ArKO) mice are deficient in estrogens due to deletion of the aromatase gene.

"We hypothesized that there may be changes in the cardiovascular system of ArKO mice because of evidence linking estrogens with improved cardiovascular outcomes and the induction of the glucocorticoid-metabolizing enzyme, 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), gene in the kidney, which is important for the regulation of blood pressure (BP)," said G.A. Head and colleagues at the Baker Heart Research Institute in Australia.

"BP and baroreflex sensitivity (BRS) in female conscious ArKO mice...

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Source: Hospital and Nursing Home Week (2004-10-28)

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