University of Naples II
Nematode genes shed light on a key regulatory complex of Alzheimer Disease
Published in Hospital and Nursing Home Week, November 18th, 2004
"The molecular adaptor Fe65 is one of the cytosolic ligands of the Alzheimer beta-amyloid precursor protein (APP), and this complex is believed to play important roles in mammalian cells. Upon cleavage of APP by specific processing activities, the complex between Fe65 and the APP intracellular domain (AICD) translocates to the nucleus. Experimental evidence suggests that the Fe65-AICD complex regulates gene transcription," scientists in Italy report.
"In Caenorhabditis elegans the orthologue of the Fe65 gene, feh-1, regulates pharyngeal activity. In fact, the rate of...
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