VA Palo Alto Health Care System
Protein with key role in cytokinesis is regulated by p53
Published in Hospital and Nursing Home Week, March 10th, 2005
Previous studies "conducted in MCF7-ptsp53 cells have demonstrated that overexpression of the wild-type (wt) p53 at permissive temperature 32 degrees C leads to growth arrest at the G2 /M phase of the cell cycle," scientists in California explained.
"To identify novel p53-regulated genes that are responsible for the p53-induced G2 /M arrest," C. Li and coauthors at the VA Palo Alto Health Care System performed a series of "cDNA microarray analyses."
The mRNA level of PRC1 "was...
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