McGill University, Montreal
Recent findings illuminate research in obesity pathogenesis
Published in Hospital and Nursing Home Week, April 7th, 2005
Study 1: Estrogen-related receptor alpha (ERR alpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine.
"The estrogen-related receptor alpha (ERR-alpha) is an orphan member of the superfamily of nuclear receptors involved in the control of energy metabolism. In particular, ERR-alpha induces a high-energy expenditure in the presence of the coactivator PGC-1alpha. However, ERR-alpha knockout mice have reduced fat mass and are resistant to diet-induced obesity. ERR-alpha is expressed in epithelial cells of...
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