Published in Hospital and Nursing Home Week, April 20th, 2006
Study 1: Proinsulin levels are elevated in type 2 diabetic patients treated with sulfonylurea.
"Hyperproinsulinemia in type 2 diabetic subjects has recently been accepted as an independent cardiovascular risk factor. Moreover, it has been confirmed that high proinsulin concentrations stimulate amylin secretion by pancreatic beta-cells and amyloid accumulation within pancreatic islets leading to impairment of pancreatic islets secretory function. The association between sulfonylureas administration and secretory function of pancreatic P-cells, especially...
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