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Breast Cancer

Research in the area of breast cancer reported from St. Mary's Hospital, Imperial College

Published in Hospital and Nursing Home Week, November 15th, 2007

"High concentrations of estrone sulfate (EIS) are present in serum of pre- and postmenopausal women. Most assays for this estrogen conjugate involve enzyme hydrolysis and chromatographic purification prior to RIA," scientists writing in the journal Anticancer Research report.

"We have compared concentrations of serum E1S in postmenopausal women measured by direct RIA or GC-MS/MS methods We analysed serum E1S concentrations using a direct 'ultrasensitive' RIA. Serum EIS concentrations were also measured by GC-MS/MS in which estrone conjugates are isolated using a solid-phase technique after which enzyme hydrolysis is employed to liberate estrone prior to GC-MS/MS...

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