Adverse Drug Reactions

Helicon Study of HT-0712 on Primate Memory Formation Reveals Significant Enhancement

Published in Hospital and Nursing Home Week, August 7th, 2008

Helicon Therapeutics, Inc. announced results from a study of memory formation in Macaque monkeys, showing that its drug, HT-0712, enhances long-term memory formation. HT-0712 already has shown a statistically significant effect on long-term memory formation in elderly human volunteers with age-associated memory impairment.

Two Phase 1 studies evaluated (i) plasma concentrations from single rising doses in 30 young and 12 elderly volunteers and (ii) 14-day chronic dosing in a second set of 12 young and 12 elderly volunteers. No significant adverse events were registered in single doses from 5 to 405 mg for young subjects, in single doses from 45 to 135 mg for elderly...

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Source: Hospital and Nursing Home Week (2008-08-07)

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