Liver Transplant

Scientists at Oregon Health & Science University publish new data on liver transplant

Published in Hospital and Nursing Home Week, August 21st, 2008

"Lactic acidosis occurs during orthotopic liver transplantation (OLT), especially during the anhepatic and early postreperfusion phases. Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase-1, indirectly activating mitochondrial pyruvate dehydrogenase," researchers in the United States report.

"This, in turn, markedly reduces systemic lactate production and, to a lesser extent, increases hepatic lactate uptake. The result is moderation of lactic acidosis in many clinical conditions. This study evaluated the efficacy of DCA in controlling lactic acidosis during OLT and improving perioperative outcome from OLT. After informed consent, 250 patients for OLT received...

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Source: Hospital and Nursing Home Week (2008-08-21)

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