Published in Immunotherapy Weekly, June 22nd, 1998
Instead of a constant systemic battle between a horde of HIV virions and a constantly surging supply of new T cells, the new model suggests that localized cells latently and chronically infected with HIV maintain virus infection and eventually lead to AIDS.
"The prevailing focus on productive-infection cycles and the view that latently and chronically infected cells are important only as reservoirs represent an overly simplistic approach to HIV dynamics," suggest William E. Paul and Zvi Grossman of the National Institutes of Health,...
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