Dietary Fish Oil

TNF secretion increased but IL-10 secretion decreased by peritoneal macrophages

Published in Immunotherapy Weekly, February 26th, 2003

"Dietary fish oil has immunomodulatory effects that are mediated in part by its effects on cytokines. Secretion of the inflammatory and the antiinflammatory cytokines tumor necrosis factor (TNF) and interleukin (IL)-10 by murine resident peritoneal macrophages was monitored after ex vivo stimulation with lipopolysaccharide.

"Macrophages were obtained from mice fed a corn oil diet containing 200 g/kg corn oil or a fish oil diet containing 180 g/kg fish oil and 20 g/kg corn oil," researchers in Iceland report.

"Dietary fish oil increased secretion of the proinflammatory cytokine, TNF, but decreased secretion of the antiinflammatory cytokine, IL-10. ...

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Source: Immunotherapy Weekly (2003-02-26)

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