Cryptococcus Neoformans

SOD influences virulence of by affecting growth within macrophages

Published in Immunotherapy Weekly, March 12th, 2003

"Superoxide dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen peroxide and molecular oxygen and has been shown to contribute to the virulence of many human-pathogenic bacteria through its ability to neutralize toxic levels of reactive oxygen species generated by the host.

"SOD has also been speculated to be important in the pathogenesis of fungal infections, but the role of this enzyme has not been rigorously investigated. To examine the contribution of SOD to the pathogenesis of fungal infections, we cloned the Cu,Zn SOD-encoding gene (SOD]) from the human-pathogenic yeast Cryptococcus neoformans and made mutants via targeted...

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Source: Immunotherapy Weekly (2003-03-12)

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