Escherichia Coli
Ler transcription at promoters results in nucleoprotein complex disruption
Published in Immunotherapy Weekly, March 12th, 2003
"The genome of enteropathogenic Escherichia coli (EPEC) encodes a global regulator, Ler (locus of enterocyte effacement [LEE]-encoded regulator), which activates expression of several polycistronic operons within the 35.6-kb LEE pathogenicity island, including the LEE2-LEE3 divergent operon pair containing overlapping -10 regions and the LEE5 (tir) operon. Ler is a predicted 15-kDa protein that exhibits amino acid similarity with the nucleoid protein H-NS," researchers in the United States report.
"In order to study Ler-mediated activation of virulence operons in EPEC, we used a molecular approach to characterize the interactions of purified Ler protein with the...
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Source: Immunotherapy Weekly (2003-03-12)
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