Lupus Erythematosus
Glomerulonephritis may result from slowed nucleosome waste disposal
Published in Immunotherapy Weekly, March 12th, 2003
According to a study from Netherlands, "Formation of antinuclear autoantibodies is a cardinal characteristic of systemic lupus erythematosus (SLE). In recent years the nucleosome has been identified as the major autoantigen, since nucleosome specific T cells have been identified, which also drive the formation of anti-dsDNA and antihistone antibodies. Nucleosome specific autoantibodies are present in a large majority of SLE patients and in lupus mice.
"Nucleosomes are formed during apoptosis by organized cleavage of chromatin. These nucleosomes, together with other lupus autoantigens; cluster in apoptotic bodies at the surface of apoptotic cells. Systemic release of...
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Source: Immunotherapy Weekly (2003-03-12)
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