T Cell Diversity

Homeostatic proliferation can also be regulated by clonal competition

Published in Immunotherapy Weekly, March 12th, 2003

"Homeostatic proliferation functions to maintain peripheral T cell numbers and is regulated by cytokines. In this study, we provide evidence that T cell homeostasis is also regulated by clonal competition. Naive polyclonal T cells divided when transferred to TCR transgenic hosts, as did monoclonal T cells when transferred to TCR transgenic hosts of differing clonotype," researchers in the United States report.

"However, T cells did not divide in hosts of identical clonotype. Transgenic T cell proliferation was inhibited in irradiated hosts of the same clonotype, while cotransferred nontransgenic T cells proliferated extensively," wrote A.E. Troy and...

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Source: Immunotherapy Weekly (2003-03-12)

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