Ovarian Cancer

Tumor lymphocytic infiltrate show depleted CD8+, CD56+ immunophenotypic profile

Published in Immunotherapy Weekly, March 12th, 2003

"Serous papillary ovarian cancer (SPC) is a highly aggressive tumor. About two-thirds of women have advanced disease at the time of diagnosis. Although many women with disseminated disease respond at first to combinations of surgery and chemotherapy, nearly 90% of tumors recur and women die of disease," researchers in Greece report.

"Updated progress in our knowledge of tumor-associated antigens and insight into mechanisms involved in immune-mediated recognition of these antigens have provided a strong starting point for using the immune system as a model for novel therapy.

"In this study we determined the immunological profile of...

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Source: Immunotherapy Weekly (2003-03-12)

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