Immunotherapy Weekly

Infectious Bronchitis - Thymulin treatments enhance lung NK cell cytotoxicity response to infection

Information Technology - MHC-peptide Interaction Database is available for stereochemistry research

Lung Cancer - Secretion of certain cytokines is high, but particularly in NSCC it decreases

Lung Injury - Work explores neuronal and inflammatory cell interplay

Lymphocyte Apoptosis - Interferon regulatory factor 4 regulates by modulating Fas-mediated apoptosis

Lysosyme Hydrolase Mutation - Screening of mucopolysaccharidosis type I patients revealed 13 new mutations

Measles - Oncolytic virus engineered to enter cell through CD20 antigen; enhances activity

Metal Allergy - Systemic and localized reactions can occur against implant materials

Multiple Sclerosis - A new infectious hypothesis involving the thymus is proposed cause of disease

Natural Killer Cells - PSK and IL-2 create different variations in PKC isoenzymes and MAPK in NKL cells

Neuroimmunologic Diseases - IL-1beta stimulates MIP-1alpha and -1beta expression in NT2-N

Occupational Exposure - Coexposure to heavy metals cadmium, cobalt, and lead create dangerous DNA damage

Oral Contraceptives - Elevated antiphospholipid antibodies may increase thromboembolism risk

Osteopetrosis - TRANCE together with IL-7 induces pre-B cells to proliferate

Pancreatic Disease - Pancreatitis-associated protein (PAP) is more common in ductal adenocarcinoma

Periodontal Disease - T cells are stimulated to express IL-17, not NF-kappaB ligand receptor activator

Periodontal Disease - Toll-like receptors 2 and 4 are found most in severely inflamed gingival tissue

Pharmacology - Variability of pharmacokinetics of high-dose oral busulfan not explained by age

Plant Immunosuppressant - An Acorus calamus extract is antiproliferative and can alter immune function

Post-Transplant Cancer - EBV DNA and mononucleosis symptoms in kidney transplant recipients may mark risk

Protein Folding - Many accessory proteins are involved in the assembly of MHC-I molecules

Protein Folding - Prion-like protein accumulates in aggresomes of cyclosporin A-treated cells

Psoriasis - Positive results announced for phase I psoriasis results

Psoriasis - Promising new results reported for Remicade

Renal Cell Carcinoma - Interferon-beta gene therapy has an antitumor effect against kidney cancer

Rheumatoid Arthritis - Chemokines have role in migration of Th1 cells into rheumatoid synovial tissue

Scedosporium Apiospermum - This emergent fungal infection must be considered in immunocompromised patients

Self-Antigen Expression - Relationship of CD8(+) T cell tolerance and cancer immunotherapy is examined

Septicemia - Oxidative stress is the factor that eventually shuts down gene expression

Septicemia - Response to endotoxin was blocked by the synthetic Lipid A analog by E5564

Sjogren Syndrome - Dry eye appears related to infiltrating lymphocytes and acinar cell apoptosis

Sjogren Syndrome - Intravenous immunoglobulin can alleviate severe ataxic sensory neuronopathy

Skin Blistering Diseases - Desmoglein is a target in autoimmunity and also in staphylococcal infection

Skin Ulceration - Leg ulcers in men may relate to Klinefelter Syndrome, are androgen treatable

Stem Cell Research - Lymphoid progenitor cells are in normal pediatric and adult human tonsils

Systemic Lupus Erythematosus - Euro-Lupus Cohort a source of ongoing information on disease

Systemic Lupus Erythematosus - Histone deacetylase inhibitors modulate renal disease, may have role in therapy

Systemic Lupus Erythematosus - MPA suppresses cytokine production of B cells, may be reason for therapy effects

T Cell-Positive Selection - TCR-dependent proofreading mechanism controls specificity and differentiation

T Cell-Stimulating Antigens - A change of one amino acid presented by MHCII molecules may trigger disease

Targeted Immunotherapy - The p53 gene encodes a nonmutated epitope recognized by tumor-reactive CTLs

Thrombocytopenia - Relapsing thrombocytopenic purpura was first indication in adult Still disease

Tobacco Use - The stress response to nicotine in periodontal fibroblasts is c-fos induction

Transplant Medicine - C1 esterase inhibitor and DAF downregulate complement-mediated xenogeneic lysis

Transplant Medicine - Human herpesviruses 6 and 7 reactivate often following transplantation

Transplantation - Interleukin-4 delays vasculopathy and fibrosis during allograft rejection

Trichinella Spiralis - The tropomyosin gene was cloned, expressed, and is antigenically reactive

Tumor Burden - Immune responses may lead to induction of T cell IL-12/IL-18 responsiveness

Turner Syndrome - Psoriasis, alopecia areata seen in association with Turner syndrome

Xenotransplantation - Induction of B cell tolerance to xenoantigens is a solution