Immunology
Islet autoreactivity deviation to cryptic epitopes protects mice from diabetes
Published in Immunotherapy Weekly, April 16th, 2003
A.H. Song and colleagues took a closer look at the loss of self-tolerance in diabetes-prone NOD mice.
They "[generated] ICA69 transgenes under control of the tetracycline-regulated tet07 minimal promoter. In vitro pilot studies showed leaky transgene expression, but addition of beta-globin genomic insulator flanks prevented leakage and dramatically enhanced transgene expression even in transient transfection, with excellent suppression by doxycycline," said the researchers.
"In vivo, the accidental...
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Source: Immunotherapy Weekly (2003-04-16)
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