Immunotherapy Weekly

Influenza Virus - Virally induced signaling cascades in host cells do not vary; should be targeted

Juvenile Idiopathic Arthritis - Another susceptibility gene was found in the HLA class I region

Leukemia - Kinetics of GVL and GVH responses were asynchronous

Leukemia - Virus-virus interaction avoids receptor requirement by retroviruses

Lyme Disease - Serum-resistant Borrelia strain evades by expressing CD59-like molecule

Lymphocyte Modulation - Melatonin counteracts PGE2 inhibition of IL-2 production in lymphocytes

MHC Class I - A cluster of TRIM genes share a conserved coiled coil region

Macrophages - Sensitivity of IL-10, IL-6 signaling define mechanism that contributes potencies

Malignant Melanoma - S100B levels are of value for monitoring patients during chemoimmunotherapy

Multiple Sclerosis - Flavonoids may be able to decrease myelin phagocytosis by macrophages

Multiple Sclerosis - Mutations in toll-like receptor 4 are at the same frequency as in normals

Mutational Analysis - Residue at position 48 of PhoQ aids switch in kinase- and phosphatase-dominance

Mycoplasma Pneumoniae - Organizing pneumonia was found and treated in a rare pediatric case

Myeloma - Human IgG2 can form covalent dimers

Myeloma - Impaired PRDI-BF1 transcription repressor identified

NK Cells - Activating and inhibitory immune synapses differ in shape and molecules present

Natural Antifungals - Ubiquitin has several antifungal activities

Nectins - Each immunoglobulin-like loop has role in cell-cell adhesion activity

Neuroactive Molecules - Astrocytes perform calcium dependent exocytosis of atrial natriuretic peptide

Neurology Vaccine - Microneme protein NcMIC3 vaccine reduces Neospora caninum infection in mice

Nonimmune Peritonitis - Agonism at MC3-R expressed on peritoneal Mphi leads to inhibition

Overactive Inflammation - G protein-coupled A2a adenosine receptors should be new therapy candidates

Parainfluenza - NucliSen Basic Kit NASBA for diagnosis with end-point and real-time detection

Parkinson Disease - Behavioral impairment measures are improved in a new MPTP mouse model

Parkinson Disease - Neuropeptide Y mRNA expression is differentially upregulated

Pneumonia - Efficacy results of DB289 in pneumonia trial released

Post-Transplant Infection - Oral valacyclovir can treat CMV disease following bone marrow transplantation

Pregnancy Loss - Genotypes are evidence that these cytokines are important in pathogenesis of RPL

Premature Birth - Formoterol inhibits proinflammatory cytokine production

Pyrogens - The rapid 'one-plate' in vitro test is readily automated

Respiratory Syncytial Virus - CXCR2 regulates RSV-induced airway hyperreactivity and mucus overproduction

Rheumatoid Arthritis - IL-17 cytokine/receptor families manipulate immune/inflammatory response

Schistosomiasis - Juvenile rhesus monkeys have lower type 2 cytokine responses than adults

Spectrometric Immunoassay - Finger lancet blood sample can be used in rapid test for apolipoproteins

Suppressor T Cells - Decision-making procedure to perform standard analyses of limiting dilution data

Systemic Lupus Erythematosus - Open-label safety study of Riquent closed

Systemic Lupus Erythematosus - PT binds to apoptotic cells surface, target of lupus anticoagulant autoantibody

T Cell Activation - A two-tier, full activation model for T cell antigen receptor signal is proposed

T Cell Activation - Self-recognition plays role in T-cell activation in presence of foreign stimuli

T Cell Antigen Receptors - Structural differences impact on receptor signaling, lineage determination

T Cell Receptors - TCR-HTA assesses levels of oligoclonality and changes in TRBV repertoires

T Cell Subset - NK-CTLs are HLA-E-restricted and may be involved in allogeneic interactions

T Cells - TCR signaling appears to relate to a highly complex conformational process

Th2 Responses - Protein kinase A regulates activation of IL-5 gene expression

Tolerogenic Thresholds - Partial tolerance is result of restricted repertoire of responding T cells

Toxoplasma Gondii - Inhibition of NF-kappa B activity results in production of IFN-gamma required

Transfusion Medicine - Agreement signed for SafeTrace Tx Transfusion Management System

Transgenic Mice - Mice provide readily available source of multiple dendritic cell subsets

Transplant Medicine - Aerosol cyclosporine improves lung function in transplant patients

Transplant Medicine - FDA approves new Rapamune labeling likely to improve kidney functioning

Transplant Medicine - Tissue typing is the key to unrelated hematopoietic cell transplantation

Trichinella Spiralis - Production of mRNA transcript for Ts23-2 gene suggests stage-specific expression

Tumor Necrosis Factor - Petrosaspongiolide M is a potent inhibitor of the NF-kappaB pathway

Type 1 Diabetes - Interleukin-4 accelerates autoimmune diabetes in mice after gene transfer

Ulcerative Colitis - New knowledge leads to novel therapies in treatment

Ulcerative Colitis - Sporadic adenoma and intraepithelial neoplasia are difficult to distinguish