Immunotherapy Weekly

Immunology - Schistosome- and malaria-specific IgG3 response link due to cross-reactivity

Immunomodulators - Cysteine-rich secretory proteins also exist worldwide in snake venoms

Immunostimulation - Human La autoantigen stimulates hepatitis C virus IRES-mediated translation

Inhibitor Proteins - Bioavailability of FasLigand inhibitor protein may translate the need for lower doses

Innate Immunity - Increased levels of antimicrobial peptides are present in neonatal skin

Insertation Mutations - Mutations reduce adherence of E coli 091:H21 strain B2F1 to epithelial cells

Leukemias - Biphenotypic acute leukemia can occur with a B-ALL subset present

Listeria Monocytogenes - Risk assessment of Listeria monocytogenes in ready-to-eat foods presented

Liver Disease - Nonmalignant liver disease and cholestasis may respond to ursodeoxycholic acid

Liver Fibrosis - Smad2 and Smad3 are differentially activated by TGF-beta in liver stellate cells

Liver/Gallstone Surgery - Delayed neutrophil apoptosis is reversed by melatonin treatment

Lovastatin - Lovastatin inhibits brain EC Rho-mediated lymphocyte migration across BBB

Lymphocytes - Th1, Th2 Lymphocyte supernatants have differential effects on human microglia

Lymphoproliferative Disease - Granular lymphocyte, TCR gammadelta positive-phenotype disease is unique

Measles - C protein peptide only elicits a vigorous, short-term IFN-gamma T-Cell response

Motorcycle Exhaust - Exhaust contains chemicals that induce apoptosis of macrophages

Multiple Myeloma - SOCS-1 is often methylated; thus negative cytokine regulation is silenced

Multiple Sclerosis -  Chlamydia pneumoniae and HHV-6 are not yet proven to be involved

Multiple Sclerosis - Beta endorphin concentrations in PBMC vary depending on clinical phenotype

Multiple Sclerosis - Caspase inhibitors can protect against apoptosis induced by caspase 3 laden CSF

Multiple Sclerosis - High MMP-9 activity characterizes short-duration relapsing and active forms

Multiple Sclerosis - Osteopontin polymorphisms may be associated with susceptibility and onset age

Multiple Sclerosis - T lymphocytes have an altered response to glutamate

Mycoplasma Pneumoniae - Current state is summarized, with special reference to molecular techniques

Myxofibrosarcoma - Immature infiltrating dendritic cells are present but not related to tumor grade

Nephrotic Syndrome - Immunoglobulin heavy chains of IgG or IgM origin can be amyloidogenic

Neuregulin - Neuregulin rhGGF2 may have anti-inflammatory, antioxidant properties in brain

Neurodegenerative Disease - Galectin-1 immunoreactivity is decreased in the skin of ALS patients

Neuronal Damage - IL-1 is up-regulated, has role in neurodegeneration by peroxynitrite production

Nicotine-induced Inflammation - Effect on inflammatory response may be related to serum corticosterone levels

Nitric Oxide Cytotoxicity - iNOS-expressing brain tumor cells may protect themselves by overinducing SOD1

Non-Hodgkin Lymphoma - Criteria can be established for different entities aided by FCM for phenotyping

Nosocomial Infections -  C. tropicalis gives high mortality despite lack of antifungal resistance

Occupational Allergens - There are respiratory symptoms and sensitization among grocers in Casablanca

Opportunistic Pathogens - Listeriosis has a large number of very different clinical presentations

Oral Microflora - Triclosan use in toothpaste does not select for resistant streptococci

P2Y Receptors - Stimulation causes anxiolytic-like effects in rat elevated plus-maze

Pathophysiology - Mannose-binding lectin and complement activation may play role in HIV infection

Penicillin Allergy - Intradermal skin tests can demonstrate allergy to beta lactamines in patients

Protein Kinases - There are a huge number of substrates that CK2 binds, both human and viral

Proteomics - Myeloid S100A9/S100A8 are involved in innate immunity, in neutrophil action

Psoriasis - Phase IIa study results are positive for topical cyclosporine conjugate

Rattlesnake Antivenom - Biphasic, venom-induced thrombocytopenia therapy was ineffective the second time

Renal Cell Carcinoma - Gangliosides expressed by SK-RC-45 involved in tumor-induced T-cell apoptosis

Renal Disease - Antivirals and steroids may halt kidney damage due to type II cryoglobulinemia

Renal Transplantation - Early steroid withdrawal with basiliximab not associated with acute rejection

Renal Transplantation - Immunosuppression not required for renal transplant from same donor as BMT

Renal Transplantation - Rejection can be stopped by blockade of macrophage colony stimulating factor

Rhabdomyosarcoma - Potent oncolytic activity of multimutated HSV G207 combined with vincristine

Rheumatoid Arthritis - Glucocorticoid-induced osteoporosis is a serious longterm complication

Schizophrenia - The hippocampus has more dentate granule cells with basal dendrites

Septic Shock - Hypothalamic/pituitary/adrenal axis is restabilized by low dose glucocorticoids

Squamous Cell Carcinoma - CD4+ and CD8+ T cells cooperate to improve prognosis of patients with ESCC

Syndenham Chorea - Cytokine pattern and anti-basal ganglia antibodies point to autoimmune disease

Syndenham Chorea - Patient anti-basal ganglia antibody found reactive to 126 and 113 kDa proteins

Tendon Injuries - Impingement syndrome of the shoulder has increased expression of tenascin-C

Thios Pharmaceuticals, Inc. - Company receives grant to develop treatments for chronic inflammatory diseases

Thrombocytopenic Purpura - Combination CTLA4-lg, cyclosporin A may be strategy for managing chronic AITP

Tobacco Carcinogen - Carcinogenesis may be induced by binding of DNA to benzo(A)pyrene diol epoxide

Uveitis - Immune recovery may cause extensive retinal neovascularization in HIV patients