Immunotherapy Weekly

Inflammatory Bowel Disease - The mu opioid receptor has strong anti-inflammatory control in colitis models

Influenza - Virus-specific plasma dendritic cells produce IFN, resist cytopathic effect

Insect Sting Allergy - Levels of IgE antibodies are not predictive for fatal anaphylaxis to hymenoptera

Kidney Transplant Risk - Polyomavirus infection can appear to be acute vascular rejection

Langerhans Cell Histiocytosis - Clonal changes in dendritic cells and proliferation are characteristic

Leukemia Inhibitory Factor - The immunoglobulin-like domain of the LIF receptor modulates LIF affinity

Liver Transplantation - It is possible to acquire hemophilia A from a hemophiliac donor liver

Lung Transplant - Statin therapy gives less inflammation, better lung function, high survival

MHC Mapping - All available short tandem repeats in the human MHC have been mapped

MHC-I Binding Sites - Heat shock protein 60 binds the MHC-Ia's Qa-1, but not on peptide Qdm

MHC-I Gene Family - Only nine MICB alleles were found to be present in the Spanish population

Mathematical Modeling - Clonal exhaustion results from interclonal regulation

Mental Disease - Frontotemporal dementia neurons have positive p62 and ubiquitin inclusions

Metabolism and Pregnancy - The human placenta is found to actively metabolize fatty acids with many enzymes

Microbial Pathogens - Mannose-binding lectin activation may not be linked to susceptibility decrease

Migraine Headache - Increased blood flow to rostral brainstem, neuronal hyperexitability involved

Multiple Myeloma - Macrophage inflammatory protein 1-alpha may be a major contributor to disease

Multiple Sclerosis - Autoimmune optic neuritis may target myelin oligodendrocyte glycoprotein

Multiple Sclerosis - Glatiramer acetate, similar to myelin basic protein, is effective MS therapy

Multiple Sclerosis - Patients have higher amylolytic activity in their IgM and IgG antibodies

Mutagenesis - Somatic mutation in V-H genes leads the way from MGUS to multiple myeloma

Mycobacterium Leprae - PCR provides efficient detection of multidrug resistance in leprosy

Novel Antimicrobials - Hepcidin-like antimicrobial peptides appear to be common in bony fish

Nutritional Therapy - Chronic fatigue syndrome may be helped by lactic acid bacteria therapy

Ophthalmology - Cells covering the iris stops damaging inflammation

Osteoarthritis - Researchers share new insights into degeneration of knee joints

Pancreatic Pain - Pain produced by chronic pancreatitis could be through neuroimmune interaction

Parkinson Disease - More postmortem cerebrovascular lesions appear unrelated to cognitive impairment

Parkinson Disease - Nicotinamide N-methyltransferase is high in cerebellum; may be pathogenic

Pathogenicity - Pathogens have unique immune manipulation methods; includes chemokine subversion

Pediatric Medicine - Autoimmune liver disease in children may lead to cholangiopathy

Pediatric Proteinuria - Prednisolone/cyclophosphamide eliminates Heinloch-Schonlein purpura nephritis

Peroxisome Biogenesis Disorder - PBD pathogenic gene for CG8 malfunction is restored with PEX26

Platelet Activation - LIM and LASP are substrates for cGK in human platelets

Platelet Reactive Antibodies - Progress is being made toward diagnostics for platelet alloimmune syndromes

Primate Evolution - Human and rhesus macaque CD1e molecules localization and function are conserved

Radioimmunotherapy - Radiolabeled monoclonal antibodies promising

Rheumatology - Adult onset Still disease may risk hepatic failure with increased IL-18 and HGF

Rheumatology - Novel orally active MMP inhibitors could knock down osteoarthritis

Rheumatology - TRAIL gene transfer reduces inflammatory tissues in arthritis models

Salivary Secretion - Mucin, non-mucin protein profiles are different following gustatory stimulation

Schistosoma Mansoni - RNA interference method allows suppression of cathepsin B expression

Seborrheic Dermatitis - New drug application submitted for Extina

Severe Combined Immunodeficiency - Gene therapy successfully treats rare boy disease

Skin Antibacterial - Beta-defensin 2 is in intercellular spaces and in keratinocyte lamellar bodies

Spermatogenesis - NF-kappa B and TNF-alpha stimulate androgen receptor expression in Sertoli cells

Streptococcus Agalactiae - Neonates and mothers have the same strain, but no strain appears more virulent

Stroke - Interferon regulatory factor-1 may be linked to cerebral ischemia and stroke

T-Cell Activation - CD8 facilitates binding of the MHC-I peptides to the T cell receptor

TMJ Disease - IL-6 in synovium may be related to the grade of joint effusion in jaw

Tissue Culture - Smooth muscle has a more normal phenotype when grown on homologous substrate

Transplant Medicine - Findings may pave way to better antirejection treatment

Transplant Medicine - Hepatologists recommend pretransplant biopsy for living donor liver transplants

Transplant Medicine - Laryngotracheal transplantation improves patient quality of life

Transplant Medicine - Reasonable prospect of benefit must be weighed against risk

Transplant Risk -  Haemophilus parainfluenza and IgA deposition may cause nephrotic syndrome

Tumor Vaccine - ICAM-1-generated antitumor immunity benefits from therapy targeting vasculature

Women's Health - Novispirin G-10 is active against Chlamydia trachomatis and vaginosis agents

Wound Healing - Fibroblast growth factor receptors FGFR1, 2 are in healing mouth myofibroblasts