Immunology
CD44 mediates CCL5-induced cell activation and HIV infectivity enhancement
Published in Immunotherapy Weekly, October 1st, 2003
"The CC-chemokine RANTES (regulated on activation normal T-cell expressed and secreted; CCL5) transduces multiple intracellular signals," scientists in Switzerland noted. "Like all chemokines, it stimulates G protein-coupled receptor (GPCR) activity through interaction with its cognate chemokine receptor(s), but in addition also activates a GPCR-independent signaling pathway."
In a recent study, B. Roscic-Mrkic and colleagues at the University of Zurich found that "the latter pathway is mediated by an interaction between RANTES and glycosaminoglycan chains of CD44."
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Source: Immunotherapy Weekly (2003-10-01)
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