Published in Immunotherapy Weekly, October 1st, 2003
According to published research from Italy, "Anti-Ras intracellular antibodies inhibit cell proliferation in vivo by sequestering the antigen and diverting it from its physiological location. Here we demonstrate that strongly aggregating single-chain antibody fragments (scFv), binding to Ras, induce apoptosis, and this effect is strictly related to the antibody-mediated aggregation of p21Ras."
"Proteasomes are quickly recruited to the newly formed aggregates, and their activity is strongly inhibited," reported Alessio Cardinale...
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