Immunology

Proteasome dysfunction in cytotoxicity mediated by anti-Ras antibodies

Published in Immunotherapy Weekly, October 1st, 2003

Scientists have found evidence that proteasome dysfunction in cytotoxicity is mediated by anti-Ras intracellular antibodies.

According to published research from Italy, "Anti-Ras intracellular antibodies inhibit cell proliferation in vivo by sequestering the antigen and diverting it from its physiological location. Here we demonstrate that strongly aggregating single-chain antibody fragments (scFv), binding to Ras, induce apoptosis, and this effect is strictly related to the antibody-mediated aggregation of p21Ras."

"Proteasomes are quickly recruited to the newly formed aggregates, and their activity is strongly inhibited," reported Alessio Cardinale...

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Source: Immunotherapy Weekly (2003-10-01)

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