Stem-Cell Research

Allergy-induced CCR3 expression may stimulate bone marrow stem-cell migration

Published in Immunotherapy Weekly, October 8th, 2003

Allergy-induced CCR3 expression may stimulate bone marrow stem-cell migration.

"There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response," researchers in Canda explained.

"To study mechanisms of progenitor cell mobilization in allergic reactions," R. Sehmi and colleagues at McMaster University "investigated fluctuations in the expression of the eotaxin receptor, CC chemokine receptor 3 (CCR3), on CD34+ cells from stable...

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Source: Immunotherapy Weekly (2003-10-08)

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