Immunotherapy Weekly

Guillain-Barre Syndrome - Cases of Guillain-Barre syndrome can have pleocytosis or CSF granulocytes

HIV/AIDS Dementia - HIV and IL-1beta regulate astrocyte FasL expression through the NF-kappa B pathway

HIV/AIDS Immunotherapy - DCs loaded with yeast-derived HIV particles immunogenic during chronic infection

HIV/AIDS Pathogenesis - HIV Vpu prevents apoptosis of infected CD4 cells

HIV/AIDS Pathogenesis - Prognostic CCR5 mutations affect co-receptor expression

HIV/AIDS Therapy - LPS-based assay provides accurate measure of HIV-specific immunity

HIV/AIDS Vaccine - Mucosal delivery of HIV-1 Tat protein elicits strong immune response

Hair Growth - Hair follicle dermal papilla cells, follicular keratinocytes express PDGF

Hantavirus - Experimental vaccine elicits strong antibody response in primates

Helicobacter Pylori - Dyspepsia symptoms come from high H. pylori prevalence in Kenya

Hemolytic Activity - Atlantic halibut and sea bass serum are capable of hemolyzing blood

Henoch-Shonlein Purpura - Immunoglobulin A1 multiple myeloma patients can get Henoch-Schonlein purpura

Hepatitis - $2.4 million, phase II, SBIR grant will help identify hepatitis-C drugs

Hepatitis A Vaccine - Hepatitis A vaccination effective at preventing disease

Hepatitis A Vaccine - Vaccine cost-effective in preventing secondary hepatitis A infection

Hepatitis B Vaccine - Hepatitis B vaccination less effective in healthy homosexual men

Immune Modulator - Proteinase-activated receptors have many roles when on immune cells, fibroblasts

Immunogenetic Research - Variations, polymorphism in major histocompatibility complex are being mapped

Immunology - Autoantibodies transform endothelial cells in autoimmune liver diseases

Immunology - Brucellosis, doxycycline, or both may trigger autoimmune hepatitis

Immunology - Hepatitis C virus core antigen is highly stable after sample collection

Immunology - Interleukin-10 genotypes mark the formation of HCV-related fibrosis

Immunology - Mucosal immune response occurs outside of Peyer patches

Infant Formula - Milk product allergenicity is effectively removed by hydrolysis with proteases

Inflammatory Bowel Disease - Signal transducers and activators of transcription play a role in Crohn disease

Influenza - Influenza-associated encephalopathy may be linked to cytokine transcription

Influenza - Novel flu treatment eliminates symptoms in mice

Influenza - Phase III data for influenza vaccine presented at conference

Influenza Vaccine - Health Canada gives approval to begin field trial of FluINsure

Influenza Vaccine - Influenza and pneumococcal vaccines reduce mortality in elderly people

Information Technology - Differentially expressed genes can be analyzed for with AtlasImage software

Inherited Disease - Thrombocytopenia appears to be linked to chromosome 22q11.2 deletion syndrome

Innate Immunity - Toll-like receptors are targets for immunomodulating innate immunity disorders

Interferon - Proinflammatory IFN-gamma also has an array of anti-inflammatory functions

Leukemia Therapy - Novel assay may improve post-SCT immunotherapy for relapsed leukemia

Lipid Studies - Ganglioside uptake by leukocytes may lead to impaired cellular immunity

Malaria Vaccine -  Plasmodium vivax adapted to Aotus monkeys aids malaria vaccine development

Malignant Melanoma - Laminin, hyaluronan, tenascin-C, collagen are serologic markers for melanoma

Market Analysis - Pharmaceutical innovations have advanced the treatment of eight major diseases

Mathematical Modeling - Limiting diversity of antigen presentation appears to enhance immune efficacy

Monoclonal Antibody Research - High attrition rates of pipeline drugs dampen oncology research activity

Movement Disorders - Physiologic models may help understand pediatric movement disorders

Multiple Sclerosis - Betaseron gains FDA approval for pre-filled diluent syringe

Multiple Sclerosis - MS has multiple loci of modest effect best found by a meta-analytical approach

Myocardial Infarction - Study: Expanded population of cord-blood stem cells may treat heart disease

Neurodegenerative Disease - NGF-like immunoreactivity increases with nicotine in animal model brain

Non-Hodgkin Lymphoma - Capital investment to be used in part for cancer vaccine development

Oral Health - Hepatitis C virus infection is not a direct cause of sialadenititis

Oral Warts - IND application filed to test oral interferon alpha

Osteoarthritis - Biopharm company releases phase II study results of osteoarthritis drug

Osteoarthritis - Celebrex associated with a nine-fold lower number of bowel lesions

Osteoarthritis - Siblings at increased risk of knee osteoarthritis

Pain Medicine - Pain therapy may soon involve the targeted use of neurotoxic molecules

Personnel - Biopharmaceutical firm names Anthony Komaroff, MD, to scientific advisory board

Personnel - Canadian biopharma company appoints scientific and medical advisory board

Placental Enzymes - AMP-deaminase from human placenta appears to be the same as the one from liver

Plasma Registry - French plasma exchange system monitors use, complications, permits studies

Platelet Functions - There may be links between inflammation, platelet function, and thrombosis

Rheumatoid Arthritis - Intramuscular gold therapy can cause reversible acute thrombocytopenia, too

Rheumatoid Arthritis - Phase II clinical trial with MLN1202 begins in RA patients

SARS - Biopharmaceutical company manufacturing SARS vaccine for research center

SARS - Serologic response to severe acute respiratory syndrome virus may be delayed

Septicemia - Septicemic lymphopenia is due to Th1 cell apoptosis, creating a shift to Th2

Serine Protease Inhibitors - Nafamostat mesilate can suppress upregulated NF-kappa B and nitric oxide

Serum Proteins - Secreted CD155 can have a liver origin, may be involved in antiviral defense

Snakebite - Company announces new shipment of CroFab antivenom

Stem-Cell Research - Transduced progenitor cells give rise to ones that express recombinant protein

Streptococcal Risk - Parkinson disease symptoms may occur following streptococcal pharyngitis

Streptococcal Vaccine - Group A streptococcal C5a peptidase is effective vaccine antigen

Surfactant Protein A - Lung SP-A aids alveolar macrophage phagocytosis, but lowers inflammation

Testicular Cytokine - Granulocyte-macrophage colony stimulating factor affects sperm motility

Therapeutic Potential - Heat shock protein 70 can provide peptides to antigen presenting cells

Thyroiditis - Most thyroiditis cases are linked with autoimmune disease, few are infective

Transfusion Medicine - Refrigerating transfusion blood induces apoptosis, may cause immunosuppression

Transplant Medicine - Soon immunosuppression will be replaced or reduced by use of tolerance induction

Treatment Risks - Chemotherapy may bring on complications relating to infection and bleeding

Trimethoprim Resistance - Dihydrofolate reductase genes can be detected easily by PCR and RFLP

Tuberculosis Immunology - TNF-alpha helps contain infection in pleural TB patients

Tuberculosis Pathogenesis -  M. tuberculosis virulence linked to mitochondrial cytochrome c release

Tuberculosis Pathogenesis - MTSA-10 blocks macrophage B7.1 expression and NO release

Tuberculosis Vaccine - Lentinan stimulates host defense against tuberculosis infection

Umbilical Cord Blood - Cord blood mast cells release I-309 after IgE exposure

Vaccine Delivery - Delivery of antigens onto bare skin may provide painless vaccination

Vaccine Development - Human T-cells recognize N-terminally Fmoc-modified peptide

Vaccine Development - Natural autoantibodies can predict the outcome of immune response

Vaccine Development - Recent advances in automated solid-phase carbohydrate synthesis reviewed

Vaccine Development - Simultaneous measurement of pneumococcal polysaccharide antibodies reported

Wounds - Presurgery stress linked to signs of slow healing