Immunotherapy Weekly

HIV/AIDS Therapy - Levels of anti-p24 IgG1 may mark HAART efficacy

Haemophilus Ducreyi -  H. ducreyi cytolethal distending toxin can be blocked by CdtA-CdtC complex

Helicobacter Pylori - A complete H. pylori cag pathogenicity island confers greater disease

Helicobacter Pylori - Gastric mucosa reduces IL-4 when faced with Helicobacter pylori with cag

Hematology - Healthy humans can also make anti-factor VIII antibodies with CD4+ T cells

Hematology - Joint TRA-418 receptor antagonist, agonist function increase antiplatelet action

Ichthyosis - Several SPINK5 mutations occur in Netherton syndrome; prenatal test is possible

Imaging - Company reports data on ProstaScint molecular imaging agent

Immunology -  L. pneumophila acts on a protein kinase, stops macrophage IL-12 production

Immunology -  P2X7 mutation enables mycobacterial survival in host cell

Immunology - Albumin has innate immunity function, inhibits B. dermatitidis yeast growth

Immunology - Beryllium dermatitis may contribute to pulmonary, noncutaneous reactions

Immunology - Company discovers orally active small molecules for autoimmune diseases

Immunology - Company identifies synthetic immunostimulatory motif in oligonucleotides

Immunology - IL-15Ralpha needed for Ly-49 induction on NK cell progenitors

Immunology - Microarrays allow the analysis of gene patterns in tolerized cardiac grafts

Immunology - Monoclonal antibody protects against S. aureus infections

Immunology - STAT5 required for tolerance in mice

Immunology - Transfected tumor cells boost antitumor responses in lung cancer patients

Immunology - Umbilical cord blood cells respond weakly to TLR-3 and -4 ligands

Immunosuppression - Canadian biotech adds third drug candidate to its immunosuppressive pipeline

Infection - Ranbaxy markets amoxicillin and clavulanate potassium tablets

Infectious Disease -  H. ducreyi can give pustule or resolution regardless of phagocytosis level

Infectious Disease - Ocular toxoplasmosis can be treated to eliminate deterioration of vision

Inflammatory Diseases - Macrophage migration inhibitory factor works to modulate inflammatory response

Irritable Bowel Syndrome - Possible genetic link studied

Kidney Disease - Understanding the role of complement in renal disease may lead to better therapy

Legionnaires Disease -  Legionella pneumophila LvhB2 is involved in infectivity efficiency at 30 degrees C

Liver Transplantation - New drugs would help graft recipients with recurrent hepatitis C infection

Lymphangiogenesis - VEGF-C may be involved in tumor cell dissemination

Mergers and Acquisitions - Omnicare to acquire Arlington Clinical Pharmacy

Multiple Myeloma - MM antigen HM1.24 loaded in adeno-associated virus produces anticancer T cells

Multiple Myeloma - Unrelated stem-cell transplantation can be effective for MM patients

Multiple Sclerosis - Behavior of neural stem cells during MS characterized

Multiple Sclerosis - CSF in isoelectric focusing assay with immunoblot allows better MS diagnosis

Multiple Sclerosis - New medical insights and advanced technologies provide hope for MS

Nasopharyngeal Carcinoma - NPC Spanish patients positive for EBV express p53 in late tumor stage

Nephrotic Syndrome - Proteinuria in nephrotic syndrome, not hematuria, shows lowered podocin level

Neuroendocrine tumors - Neuroendocrine tumors of the appendix are easily curable by appendectomy

Neurology - Signal patterns that control phagocytosis are important in CNS immunity, repair

Neuroscience - In multiple system atrophy; alpha, beta-synuclein accumulate in different cells

Neurotransmitter Autoantibodies - A wide range of psychiatric and nerve disorders have autoantibodies to serotonin

Oncology - An anticancer compound found in garlic induces apoptosis by binding tubulin

Osteoarthritis - FDA issues approvable letter for Orthovisc

Otorhinolaryngology - Allergies and autoimmune disease can affect the ears

Periodontics - Human gingival fibroblast CD73 is involved in adenosine production

Personnel - Glenn R. Larsen, PhD, named chief scientific officer

Preventive Medicine - NSAIDs inhibit angiogenesis by suppressing molecular switches

Psoriasis - Alefacept effective in treating patients with psoriasis

Psoriasis - Medication provides effective treatment for moderate to severe psoriasis

Quality Assurance - Practice parameters are being developed for managing pediatric allergy, asthma

Radiation Exposure -  Chelidonium majus CM-Ala may protect against radiation exposure

Radiation Exposure - Bacteria related to Sulfobacillus spp. can survive radiation from uranium

Respiratory Distress Syndrome - Exhaled nitric oxide can be used to monitor preterm infant respiratory distress

Rheumatoid Arthritis - AVR118 inhibits inflammatory arthritis

Rheumatology - TNF etanercept can induce lupus erythematosus, autoimmune symptoms

Rickettsias -  Anaplasma marginale varies membrane antigens; may explain disease cyclicity

Salmonella Enterica Typhi - Commensal bacterial products can increase invasion potential of S. enterica

Squamous Cell Carcinoma - Human papillomavirus type 16 is prevalent in adult tonsil, not oral cavity SCC

Stem-Cell Therapy - Therapeutic cloning generates cloned, compatible stem cells in bovine model

Stem-Cell Transplantation - BG/BCNU induces in vivo selection of MGMT(P140K) lentivirus-transduced stem cells

Stem-Cell Transplantation - Combination CTL/endothelial cell test identifies GVHD

Stem-Cell Transplantation - Cyclophosphamide treatment reduces serum cyclosporine A levels

Stem-Cell Transplantation - RIST associated with reduced risk of post-transplant hemorrhagic cystitis

Streptococcus Pneumoniae -  S. pneumoniae virulence involves control of oxygen by the MicAB kinase

Sun Exposure - White renal transplant patients on calcium channel blockers risk photo-damage

T-Cell Activation - LFA-1 controls T cell activation threshold, IL-2 production, Th1 differentiation

T-Cell Hyporeactivity - Janus kinase inhibitors inhibit dendetric cell maturation, induce T-cell hyporeactivity

TLR Regulator - X-ray crystallography reveals dimerization and large acid pocket in IRF-3

Thrombocytopenia Purpura - Antigenic spacer domains in ADAMS-13 are needed to cut von Willebrand factor

Tobacco Use - Family-based research is required to investigate factors in tobacco dependency

Transcription Factors - Eomesodermin is involved in differentiation, function of effector CD8+ T cells

Transfusion Medicine - Extent of hospital FNHTR reporting in France determined

Transplant Medicine -  Xylohypha bantiana can cause curable brain abscess similar to aspergillosis

Transplant Medicine - CD80 and CD154, but not CD86, are associated with rejection in liver allografts

Transplant Medicine - Dendritic cell manipulation can induce EBV-specific T cells to reduce PTLD risk

Transplant Medicine - Polyomavirus nephropathy, tubulitis benefit most from lower immunosuppression

Transplant Medicine - Transplant-associated porokeratosis can lead to squamous cell carcinoma

Tuberculosis Pathogenesis - Mycobacterial phagosome maturation arrest facilitated by p38 MAPK

Tuberculosis Pathogenesis - TNF-alpha-induced MMP-9 secretion creates tuberculous granulomas

Tumor Markers - Pancreatic endocrine neoplasms are more likely to have p27 if metastasizing

Vector Screening - Serodiagnostic results for hantavirus in different rodents depends on reagents