Immunotherapy Weekly

Cancer Immunology - Researchers unlock key secrets showing how tumors hide from immune system

Amyotrophic Lateral Sclerosis - MCP-1 levels are elevated in CSF of ALS patients, due to microglial activation

Transplant Medicine - Researchers identify transplantation antigens among Sioux Indians

Transplant Medicine - Sibling donates marrow to two other brothers

Tuberculosis - ANA-positive pleural effusion reported in TB patient

Tuberculosis Animal Model - Reasons for TB susceptibility of DBA/2 mice identified

Tuberculosis Vaccine - In vitro evolution of BCG vaccines reviewed

Tuberculosis Vaccine - RD1-encoded protein TB27.4 from M. tuberculosis elicits immune response

Tuberculosis Vaccine - Sonicate antigens from M. tuberculosis stimulates strong T-cell response

Typhoid Fever - Mimotopes of antigen of Salmonella enterica identified from peptide library

Vaccine Adjuvant - New method for screening mucosal adjuvants developed

Vaccine Delivery - Spore germination provides novel route for antigen delivery

Angiology - Fibrosing mediastinitis, vena cava thrombosis can occur in Behcet disease

Vaccine Safety - Some vaccines additives cause rare allergic reactions

Vaccine Safety - Whole cell pertussis vaccine lowers incidence of atopic disorders

West Nile Virus Vaccine - Japanese encephalitis vaccine partially protects against West Nile

Wound Care - Amino acid arginine is involved in several processes in wound healing

Antibacterial Activity - TLR-5 recognizes a 13 amino acid, functional, conserved site on flagellin

Antibody Generation - IgA changes quantity from infancy to childhood; in saliva, serum, polymeric form

Apoptosis - Fas apoptosis activation involves microaggregates if by anti-Fas Ab, not FasL

Arthritis - Company submits NDA for ARCOXIA

Asthma - Blocking mucus secretion in asthma

Asthma - New drug application submitted to FDA for Alvesco

Autoimmune Disease - NIH names Alabama college national autoimmunity center of excellence

Brain Immunology - Guanylyl cyclase in astroglial cells is lowered by IL-1 beta, LPS

Mycobacteria -  M. tuberculosis and M. marinum induce differential macrophage IL-8 expression

Breast Cancer - Moderate neutropenia with adjuvant CMF improves early breast cancer survival

Burns - Integra dermal regeneration template for deep hand burns is effective

Cell Biology - CD1 molecules act as "middleman" to get lipids to immune cells

Chagas Disease - Virulence factor identified

Chlamydia Pneumoniae -  C. pneumoniae may play a role in CNS diseases such as Alzheimer and MS

Colon Cancer - Two novel tumor-associated antigens recognized by T lymphocytes identified

Crohn Disease - Targeting alpha-4 integrin is novel treatment for inflammatory bowel disease

DPT Vaccine - dTpa vaccine better tolerated than DTPw vaccine in children

Dengue Fever - Mutations enhance replication of dengue virus in Vero cells

Endocrinology - Immune-responsive gene 1 plays a crucial role in uterine implantation

Cancer Vaccine - RNA-loaded dendritic cells used for cancer immunotherapy

Facilities - Dermatology company begins construction of new research facility

Fungal Infections - Aspergillosis can occur in sinuses; serological and culture positivity is low

Gastric Cancers - IP3R3 may be involved in the peritoneal dissemination of gastric cancer

Geriatrics - Thymic stromal macrophages and dendritic cells are not greatly altered with age

HIV/AIDS Cancer - Rare NHL types can underlie kidney failure in HIV patients

HIV/AIDS Immunology - Antiviral CD8 cell activity after acute HIV infection elucidated

HIV/AIDS Immunology - CTL epitope specificity determines extent of HIV suppression

HIV/AIDS Receptor Studies - Structure of gp120-CCR5 complex elucidated

HIV/AIDS Therapy - CD4 cell nadir predicts response to subcutaneous rIL-2 treatment

Chronic Liver Disease - A new synthetic cannabinoid derivative stops inflammatory liver damage

HIV/AIDS Vaccine - Ii-Key/MHC class II epitope hybrid peptide vaccines show promise for HIV

HIV/AIDS Vaccine - Scientific challenges impeding HIV vaccine development reviewed

Helicobacter Pylori - Pediatric H. pylori Cag A total IgG, IgG subclass, indicate pathology type

Hepatitis A Vaccine - Virosomal hepatitis A vaccine (Epaxal) protects against infection

Hepatitis B Vaccine - Hepatitis B DNA vaccine induces protective responses in non-responders

Hepatitis C Virus - Peripheral blood cells may act as HCV reservoir in HIV+ hemophiliacs

Hepatitis C Virus - Pharmaceutical company expands hepatitis C virus patent portfolio

Herpesvirus Vaccine - LEAPS vaccine with HSV-1 glycoprotein D epitope elicits protection

Human Papillomavirus Vaccine - HPV16 L2 peptide shows promise as human papillomavirus vaccine