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Anti-inflammatory

Prostaglandin may worsen lung injury induced by lipopolysaccharide

Published in Immunotherapy Weekly, February 4th, 2004

15-Deoxy-Delta12,14-prostaglandin J2 may exacerbate acute lung injury induced by lipopolysaccharide in mice.

According to recent research published in the European Journal of Pharmacology, "15-deoxy-Delta12,14-prostaglandin J2 (15d-prostaglandin J2 ) has received attention for its anti-inflammatory properties. The present study investigated the efficacy of 15d-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in mice. ICR mice were administered with 15d-prostaglandin J2 (10 microgram/kg, 100 microgram/kg, or 1 mg/kg) before intratracheal challenge with...

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