Systemic Lupus Erythematosus
Lupus T cells upregulate COX-2 to prevent apoptosis
Published in Immunotherapy Weekly, May 26th, 2004
"Autoimmune T-helper cells drive pathogenic autoantibody production in systemic lupus erythematosus (SLE), but the mechanisms maintaining those T cells are unknown," scientists in Chicago explained. "Autoreactive T cells are normally eliminated by functional inactivation (anergy) and activation-induced cell death (AICD) or apoptosis through death receptor (Fas) signaling. However, mutations in the genes encoding Fas and its ligand (FasL) are rare in classical SLE4.
"By gene microarray profiling, validated by functional and biochemical studies," L.T. Xu and colleagues at Northwestern University...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Immunotherapy Weekly
Source: Immunotherapy Weekly (2004-05-26)
More Articles from Immunotherapy Weekly
- Drug Development
Aloe saponaria mannan has potent anticancer effects - Drug Development
Granzyme B shows promise as immunotoxin - Immunology
CD28 not directly involved in NK cell response to lipopolysaccharide - Immunology
MEF2 mediates calcium-dependent IL-2 gene transcription in T cells - Stem-Cell Research
Coculture system successfully induces embryonic stem cell differentiation - AIDS/HIV Therapy
Lymphocytes in transgenic mice are resistant to viral infection - More from this issue of Immunotherapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
