Published in Immunotherapy Weekly, May 26th, 2004
This enzyme is "a potent apoptosis-inducing serine protease of cytotoxic lymphocytes," scientists in Germany explained. "Following receptor-mediated endocytosis, GzmB is supposed to enter the cytosol through perforin-mediated membrane disruption."
In a recent study, F.C. Kurschus and colleagues at the Max Planck Institute of Neurobiology "investigated whether retargeting of GzmB to Lewis Y positive surface receptors could lead to perforin-independent target cell death.
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