Drug Development
Granzyme B shows promise as immunotoxin
Published in Immunotherapy Weekly, May 26th, 2004
This enzyme is "a potent apoptosis-inducing serine protease of cytotoxic lymphocytes," scientists in Germany explained. "Following receptor-mediated endocytosis, GzmB is supposed to enter the cytosol through perforin-mediated membrane disruption."
In a recent study, F.C. Kurschus and colleagues at the Max Planck Institute of Neurobiology "investigated whether retargeting of GzmB to Lewis Y positive surface receptors could lead to perforin-independent target cell death.
"We coupled recombinant GzmB to the Lewis Y-binding antibody dsFv-B3," according to the report....
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Source: Immunotherapy Weekly (2004-05-26)
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