Immunology

CD28 not directly involved in NK cell response to lipopolysaccharide

Published in Immunotherapy Weekly, May 26th, 2004

CD28 is not directly involved in lipopolysaccharide-induced NK cell activity.

Researchers in England had "previously shown that human CD3^-CD56⁺ and CD3⁺CD56⁺ cells from some individuals mount vigorous proliferative responses to lipopolysaccharide.

"Such responses have been blocked by the presence of cytotoxic T-lymphocyte antigen-4 immunoglobulin fusion protein in the cultures, implicating a role for B7-mediated costimulation," according to M.R. Goodier and coauthors at Chelsea and Westminster Hospital in London. In their subsequent study, the collaborators confirmed "this inhibition of natural killer (NK)...

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Source: Immunotherapy Weekly (2004-05-26)

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