Immunotherapy Weekly

Immunology - Distribution of effector CD4 cells characterized

Immunology - FTY720 may increase efficacy and tolerability of immunosuppressive regimens

Immunology - Factors influencing survival of cells expressing low-affinity TCR identified

Immunology - Gel phase lipid rafts identified in neutrophil lamellipodia

Immunology - HIP-55 key novel component of synapse modulating T-cell activation

Immunology - Hyperfiltration not the rule following single kidney transplantation

Immunology - IL-4 determines need for WSX-1 in Th1 response to Leishmania

Immunology - Interferon-beta gene delivery blocks the formation of autoimmune myocarditis

Immunology - Livers could retain activated CD8+ T cells with Kupffer cell interference

Immunology - Medicinal fungus water extract promotes immunity and inhibits tumor metastasis

Immunology - NKG2D likely dendritic cell target-recognition molecule

Immunology - Novel protein inhibits TIFA activity

Immunology - OX40 costimulates CD8 T-cell activity

Immunology - P2X₇ receptor activator LL37 promotes IL-1beta release

Immunology - Proinflammatory phenotype in niSMCs result in increased leukocyte recruitment

Immunology - Roles of TCR and Notch signaling in positive selection clarified

Immunology - STAT5 signaling involved in IL-7 receptor-dependent B-cell development

Immunology - TEPA study supports current phase I/II leukemia trial in the U.S.

Immunology - The mast cell directs the immune response

Immunology - Thymocyte-intrinsic genetic factors regulate CD8 T-cell lineage commitment

Immunology - sIg light chain restriction may not indicate mature B-cell phenotype in ALL

Immunosuppression - Cyclosporin and tacrolimus have equivalent results in lung transplantation

Immunosuppression - Cyclosporine remains the cornerstone of immunosuppression

Immunosuppression - Successful kidney transplants increase with cyclosporine experience

Infectious Disease - Listeriolysin O induces lymphocyte apoptosis

Infectious Disease - Transmission cycles of Pneumocystis jirovecii infections are linked

Infectious Disease Vaccine - Vaccines for infectious diseases with cutaneous symptoms reviewed

Inflammation - recHDLs reduce inflammation associated with ischemia/reperfusion and colitis

Inflammatory Bowel Disease - Autoimmune regulator gene mutations not linked to pathogenesis

Influenza - APIC calls on healthcare facilities to improve flu-shot rates among workers

Influenza - New influenza immunization guidelines hailed by vaccine maker

Influenza - Study: Intranasal influenza vaccine shows higher efficacy rate

Influenza Vaccine - Influenza challenge of Th2/Tc2 response causes Th2/Tc1 response in lung

Ischemia - Stathmin marks cell proliferation in the recovery phase of renal failure

Lactococcus - IL-12 produced and secreted in active form by Lactococcus lactis

Leishmaniasis - Gene encoding protective Leishmania amazonensis protein characterized

Leukemia Pathogenesis - IL-7 induces apoptosis of 697 cells expressing dominant-negative STAT5

Lupus - Coronary vasculitis with acute myocardial infarction reported in SLE patient

Melanoma - Melanoma cells secrete FasL and APO2L/TRAIL on microvesicle surface

Melanoma - TAP-1 technology corroborated in models of skin cancer

Meningitis Vaccine - Polysaccharide-protein conjugates protect against N. meningitidis

Metabolic Pathway - Organelles are involved in tissue differentiation

Multiple Sclerosis - Bax ablation ameliorates murine experimental autoimmune encephalomyelitis

Multiple Sclerosis - CD25+ regulatory helper T cells reduced in MS patients

Multiple Sclerosis - Mice expressing myelin glycoprotein protected against encephalomyelitis

Mumps - Analysis of mumps virus isolates during Swiss outbreak reported

Mumps - Study of mumps outbreak due to genotype H in Korea in 1999 reported

Mumps - Two new genotypes of mumps virus in Japan proposed

Mycobacterium Vaccine - Profiling of leprosy and tuberculosis patients aids vaccine development

Myelodysplastic Syndrome - Granulocyte DNA models may facilitate MDS diagnosis

Neural Inflammation - Butyrate is anti-inflammatory in primary, brain-derived microglial cells

Neurology - MCP-1 involved in development of mechanical allodynia induced by nerve injury

Neuroscience - Autoimmune nature of Tourette syndrome, PANDAS called into question

Neuroscience - Novel anti-peptide antibody enables CCK1R immunolocalization

Non-Hodgkin Lymphoma - Phase II trial with VELCADE and Rituximab begins

Organ Transplants - Cryogenic organ banking getting closer

Osteoarthritis - New research on acetaminophen presented at pain societies meeting

Ovarian Cancer - Monoclonal antibody under study as ovarian cancer immunotherapeutic

Pancreatic Islets - Advances and immunological challenges of islet transplantation outlined

Pancreatic Islets - Immunosuppression for pancreatic islet transplantation reviewed

Pancreatic Islets - Resistin levels return to normal after islet transplantation

Peanut Allergy - Beta-blocker therapy beneficial for peanut allergy patients with heart disease

Personnel - Gary L. Crocker joins board of Cambridge, Massachusetts-based biotech

Pertussis Vaccine - Acellular pertussis vaccines possess increased safety in children

Polio Vaccine - Polio model through mucosal infection in transgenic mice developed

Prostate Cancer - Dendritic cell vaccine for prostate cancer immunotherapy possible

Proteomics - Mass spectrometry gas-phase fractionation enhances protein identification

Proteomics - Matrix gene and protein expressions change in radiation-exposed skin

Proteomics - POROS bead-based FACS system facilitates immunoadsorbent development

Proteomics - SAF-1 regulates cell cycle progression through p21 induction

Rheumatoid Arthritis - Humira significantly slows disease progression in arthritis patients

Rheumatoid Arthritis - Phase I testing of oral CCR2 antagonist begins

Skin Cancer - Alpha-tocopherol may offer some protection against less aggressive melanomas

Skin Itch, Inflammation - FDA grants approval to market fluticasone cream

Smallpox Vaccine - Smallpox vaccine adverse effects linked to cytokine level alterations

Stem-Cell Research - Endodermal progenitors differentiate into hepatic and pancreatic lineages

Stem-Cell Research - Genetic profiling of hair follicle stem cells yields treatment targets

Stem-Cell Research - Many brainstem neurons express functional MOR or DOR receptors or both

Stem-Cell Research - Shock wave-promoted bone formation activates ERK and p38 kinase

Stem-Cell Transplantation - Children recovering from stem-cell transplants suffer diminished resistance

Stem-Cell Transplantation - Pretreatment with hydroxyurea lowers rejection incidence in sickle cell disease

Theileriosis - Indirect ELISA for diagnosing tropical theileriosis developed

Tick-Borne Disease - Titration of Theileria parva tick-derived stabilates reported

Transfusion Medicine - FACS assay suitable for HPA 1a screening

Transgenics - Pentraxin 3 helps control fungal recognition and phagocytosis

Transplant Medicine - Report: New approach has lung recipients taking far fewer drugs

Tumor Marker - Clinical marker CAF-1 distinguishes quiescent from proliferating cells

Tumor Suppression - PTEN is physically associated with platelet-derived growth factor

Tumorigenesis - Autocrine/paracrine SFRP 2 induces cellular resistance to apoptosis

Vaccine Delivery - Live genetically modified bacteria may act as drug delivery tools

West Nile Virus - Pathogenesis and therapeutic options for West Nile virus reviewed

Xenotransplantation - Lipoprotein lipase protects bovine endothelial cells from human NK cell activity