Published in Immunotherapy Weekly, June 9th, 2004
"T-cell diversity was once thought to depend on the interaction of T-cell precursors with thymic epithelial cells," immunologists in Minnesota explained. "Recent evidence suggests, however, that diversity might arise through the interaction of developing T cells with other cells, the identity of which is not known."
In their study, C. Joao and colleagues at the Mayo Clinic in Rochester found that "T-cell diversity is driven by B cells and Ig [immunoglobulin]."
"The TCR Vbeta diversity of thymocytes in mice that lack B cells and Ig is reduced to...
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