Immunology

B cells play key role in T-cell diversity

Published in Immunotherapy Weekly, June 9th, 2004

Surprisingly, B cells play a key role in the development of a broad T-cell repertoire.

"T-cell diversity was once thought to depend on the interaction of T-cell precursors with thymic epithelial cells," immunologists in Minnesota explained. "Recent evidence suggests, however, that diversity might arise through the interaction of developing T cells with other cells, the identity of which is not known."

In their study, C. Joao and colleagues at the Mayo Clinic in Rochester found that "T-cell diversity is driven by B cells and Ig [immunoglobulin]."

"The TCR Vbeta diversity of thymocytes in mice that lack B cells and Ig is reduced to...

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Source: Immunotherapy Weekly (2004-06-09)

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