Immunotherapy Weekly

Bile Duct Cancer - Serum sFas/sFasL levels have prognostic value in bile duct cancer patients

Drug Development - Novel anti-Leishmania immunotherapies show promise

HIV/AIDS Research - Antigen-specific T cells migrate away from CXCR4-binding HIV-1 gp120

Immunology - Poly(I:C) may be one of the most appropriate agents to generate stable mature DC

Immunology - Sts-1 and -2 proteins regulate TCR signaling

Multiple Sclerosis - Cytosolic phospholipase A₂ plays a key role in EAE pathogenesis

Adverse Drug Effects - Erythema multiforme-like reaction to adalimumab reported

Adverse Drug Effects - Sirolimus-induced angioedema reported

Allergy & Immunology - IgG4-switched B cells may undergo secondary switch to IgE in allergen exposure

Allergy & Immunology - Malassezia enhances natural killer cell-induced dendritic cell maturation

Allergy Medicine - Grass pollen-specific marker allergens molecularly characterized

Allergy Medicine - Two out of three prescription antihistamine users don't have allergic disease

Antibiotics - Michael Marquard named president of company's branded sub

Antimicrobials - Mucosal antimicrobial peptide expressed by chinchilla airway identified

Apoptosis - ARC protects against cell death through interaction with Bax

Arthritis - Combination drug therapy sustains disease remission

Arthritis - PA Health Department presents "State of Arthritis in Pennsylvania" report

Arthritis - Patients may be willing to exchange less effective drugs for fewer side effects

Arthritis - RehabCare Group develops strategic partnership with Arthritis Foundation

Arthritis - Study indicates double-jointedness as protective factor for hand osteoarthritis

Autoimmune Disease - Mutant NALP3 forms a highly active IL-lbeta-processing inflammasome

Bacillus Calmette-Guerin Vaccine - Guttate psoriasis-like lesions following BCG vaccination

Bacterial Endotoxin - A synthetic peptide derived from BPI: aa 148-161 neutralizes endotoxin

Bacterial Infection -  C. pneumoniae-induced IFN-gamma dependent on 88-IFN-alpha beta-STAT1 signaling

Bacteriology -  L. pneumophila Philadelphia-1 magA expression developmentally regulated

Bacteriology -  Rickettsia prowazekii Madrid E strain proteome analyzed

Breast Cancer Vaccine - Breast tumor cell destruction by herpesvirus induces antitumor immunity

Cancer Therapy - Phase II clinical trial with MDX-070 in prostate cancer announced

Cancer Therapy - Receptor tyrosine kinases offer targets for cancer therapy

Cancer Trends - Monoclonal antibody therapies continue rapid growth in cancer market

Cancer Vaccine - Adoptive transfer of anti-idiotypic T cells cure B cell lymphoma

Cancer Vaccine - Dendritic cell vaccine prevents GI tumors based on mutation

Cancer Vaccine - Multiple antigens recognized by lymphocytes identified from individual

Cancer Vaccine - mRNA-transfected dendritic cells used for cancer immunotherapy

Chronic Lymphocytic Leukemia - CAMPATH B-CLL study fully enrolled; will evaluate prolonged survival

Collaborations - Companies to develop personalized dendritic-cell vaccines

Congenital Ichthyosis - Liarozole receives FDA orphan drug status

Contraceptive Vaccine - Chitosan-plasmid DNA nanoparticles used for contraceptive vaccine

Coronavirus - SARS-CoV proteinase inhibitors may be developed from existing drugs

Cough - U.S. FDA approves 12-hour Codeprex

Crohn Disease - Bacterial flagellin is dominant antigen in Crohn disease

DNA Vaccine - Antigens with stress protein-capturing domain improve immunogenicity

DNA Vaccine - Processing of antigens delivered as DNA vaccines reviewed

Dendritic Cell Vaccine - Antibodies modulate interactions of adenovirus with dendritic cells

Dendritic Cell Vaccine - Dendritic cells and immunity to cellular antigens reviewed

Diagnostics - Proteomics-based screen identifies disease-associated humoral antigens

Endocrinology - Physical training may alter inflammatory factors/reduce delayed muscle soreness

Environmental Health - Immunologic response to inhaled endotoxins clarified

Fibromyalgia - AT-101 provides relief in fibromyalgia, chronic fatigue syndrome

Fibromyalgia - Phase II milnacipran data presented at meeting in Paris

Fungal Infection - Clinical factors predict fluconazole resistance/Candida blood infection survival

Gastroenterology -  H. pylori causes chronic gastritis in p53-knockout mice

Gastroenterology Vaccine - Apical membrane receptors in intestine are targets for vaccine delivery

Gene Expression - BTLA negative regulator of activation and/or function of hemopoietic cell types

Gene Regulation - Ets gene PEA3 assists beta-catenin-Lef-1/c-Jun in OPN transcription regulation

Genomics - Polymorphic GATA site in IL-12R beta 2 promoter region affects transcription

Gout - Cardiome receives FDA approvable letter on oxypurinol for gout

HIV/AIDS - P24 tag useful tool for purifying and detecting recombinantly expressed scFvs

HIV/AIDS Research - Association not found between CCL3-L1 absence and HIV-1 infection susceptibility

HIV/AIDS Research - Furin processing likely mechanism for inactivating extracellular HIV-1 Tat

HIV/AIDS Research - HIV-1 RT and integrase proteins interact during viral replication

HIV/AIDS Research - HIV-1 immune response differs in exposed seronegative and seropositive partners

HIV/AIDS Research - Integrase plays important role during the RT step of the HIV life cycle

HIV/AIDS Research - Potential protective effect of HLA DQB1*06 alleles on course of HIV disease

HIV/AIDS Research - Structural/thermodynamic escape mechanism found from HIV-1 protease mutation

HIV/AIDS Research - Subtype D HIV-1 isolated from untreated individual highly resistant to NNRTIs

HIV/AIDS Research - TARTAR dimer therapeutic target for treatment of HIV-1 infection

HIV/AIDS Serology - Seronegative infection and AIDS is caused by HIV-1 A2 subsubtype

HIV/AIDS Therapy - ART efficacy after protease inhibitor failure better in NNRTI-naive patients

HIV/AIDS Therapy - Atazanavir is a new option for treatment of HIV infection

HIV/AIDS Therapy - Enfuvirtide safe and effective for adult and pediatric HIV-1 infection

HIV/AIDS Therapy - HAART effects survival and surrogate markers in vertically HIV-infected children

HIV/AIDS Therapy - Methadone plus HAART can be implemented with good results in HIV-infection

HIV/AIDS Transmission - HLA-DRB1 and -DQB1 variants associated with HIV-1 transmission events

HIV/AIDS Treatment - CC-chemokine levels lack correlation with HIV-1 stage and response to treatment

HIV/AIDS-Related Conditions - Inflammatory and reactive arthropathies more prevalent in HIV infection

HIV/AIDS-Related Disease - CdCSH1p may have a role in adhesion of C. dubliniensis to fibronectin

HIV/AIDS-Related Disease - Chemokine-induced signaling pathways may mediate cell growth in Kaposi sarcoma

HIV/AIDS-Related Disease - Novel therapies developed for treatment of AIDS-related Kaposi sarcoma

HIV/AIDS-Related Disease - Prevalence of P. carinii mutations increased in the United States

HIV/AIDS-Related Disease - QTD PCR of oral-wash samples accurate and noninvasive for diagnosis of PCP

Hepatitis Virus - Novel class of phosphonate nucleosides potent and selective anti-HBV agent

Herpes Vaccine - Dendritic cell vaccine transfers herpes resistance to naive mice

Herpesvirus - Post-translational HHV-6 IE1 protein modification by SUMO peptides characterized

Herpesvirus - Theta defensins protect cells from HSV by inhibiting viral adhesion/entry

Herpesvirus Research - Kaposi sarcoma-associated herpesvirus protease highly specific

Immunogene Therapy - Immunoporters permit tumor-specific targeting

Immunology - Antiviral cytokines induce granzyme B inhibitor/PI-9/SPI-6 hepatic expression

Immunology - B cells may trigger intestinal inflammation in inflammatory bowel disease

Immunology - BAFF dependence underlies reduced survival of autoantigen-engaged B cells

Immunology - C-terminal Src kinase regulates acute inflammation and granulocyte adhesion

Immunology - CD43 regulation of T cell activation is through an intracellular mechanism

Immunology - CD8 cells have unique secretory compartment for RANTES storage

Immunology - CGRP down-regulates IL-2 and IFN-gamma and up-regulates IL-4 production

Immunology - Costimulatory receptor programmed death-1 characterized

Immunology - CpG DNA redirects class-switching towards Th1-like Ig isotype production

Immunology - Cryo-electron tomography used to characterize individual IgG molecules

Immunology - Cutaneous immune sensitization is enhanced by antigen-independent IgE effects

Immunology - DC maturation by AdV transduction enhances tumor Ag-specific T cell response

Immunology - Dendritic cell expression of Ig-like transcripts characterized

Immunology - Granzyme M mediates a novel form of perforin-dependent cell death

Immunology - HDAC6 deacetylase links tubulin cytoskeleton with immune synapse

Immunology - I175E substitution converts Newcastle disease virus HN to an F-interactive form

Immunology - IFN-alpha priming results in a gain of proinflammatory function by IL-10