Immunology

Valpha24 NK T cells of CD4+ subset develop in the early fetal thymus

Published in Immunotherapy Weekly, July 21st, 2004

Valpha24 NK T cells of the CD4+ subset develop in the early fetal thymus.

According to a study from Sweden, "Natural killer (NK) T cells are innate CD1d-restricted immune cells involved in regulation of immune tolerance, tumor immunity, and immunity to infectious pathogens. Human alpha-chain variable gene segment 24 (Valpha24) NK T cells exist in the periphery as two functionally distinct subsets: one CD4+ and one CD4- subset."

"However," J.K. Sandberg and coworkers reported, "the developmental pathway of human Valpha24 INK T cells is not well understood. We show that Valpha24 NK T cells develop in the fetal thymus. The relative number of intrathymic...

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Source: Immunotherapy Weekly (2004-07-21)

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