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Multiple Sclerosis

Cytosolic phospholipase A2 plays a key role in EAE pathogenesis

Published in Immunotherapy Weekly, July 21st, 2004

The enzyme cPLA2 plays a key role in the pathogenesis of a multiple sclerosis (MS)-like disorder in animals.

MS is "an inflammatory demyelinating disease of the central nervous system (CNS) that results in motor and sensory deficits," neurologists in Canada explained. "Although MS and its animal model, experimental autoimmune encephalomyelitis (EAE), are thought to be T cell-mediated diseases, the mechanisms underlying the lesions in the CNS are not fully understood."

In a recent study, A. Kalyvas and colleagues at the McGill University Health Centre in Montreal found that "a strong candidate as a central mediator in evoking the complex...

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