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Stem Cell Transplantation

High-dose chemotherapy with ASCT beneficial for bone and soft-tissue sarcomas

Published in Immunotherapy Weekly, September 8th, 2004

High-dose chemotherapy with allogeneic stem cell transplantation may be beneficial for bone and soft-tissue sarcomas.

According to a study from Germany, "The role of high-dose chemotherapy (HDCT) with PBSCT in the treatment of bone and soft-tissue sarcomas is not established.

"In total, 27 patients (15 female, median age at TPL 30.6 years (range: 13-59)) were analyzed (Ewing sarcoma family n=8, osteosarcoma n 6, MPNST (malignant peripheral nerve sheath tumor) n=4, synovial sarcoma n=3, liposarcoma n=2, leiomyosarcoma n=2, rhabdomyosarcoma n=1, meningosarcoma n=1)."

"Following chemotherapy and surgery complete remission (CR)...

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