Immunotherapy Weekly

HIV/AIDS Research - Virus-associated host ICAM-1 in HIV-1 dissemination depends on cellular context

HIV/AIDS Research - Vpr protein essential for HIV replication in nondividing cells

HIV/AIDS Research - gp120 conformation determines HIV-1 DH012 sensitivity to entry inhibitor IC9564

HIV/AIDS Research - tRNA(Lys) incorporation into HIV depends upon its interaction with LysRS

HIV/AIDS Screening - Rapid HIV test decreases post-exposure prophylaxis after occupational exposure

HIV/AIDS Therapy - HIV chemotherapy and prophylaxis becoming more diverse and efficient

HIV/AIDS Therapy - Nutritional supplement improves health for HIV/AIDS patients

HIV/AIDS Therapy - Orally active CCR5 antagonists inhibit HIV-1 in fusion assay

HIV/AIDS Vaccine - Generex expands HIV vaccine efforts with MGH investigator

HIV/AIDS-Associated Disease - Liver disease important cause of morbidity/mortality in HIV infection

HIV/AIDS-Associated Disease - Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy

Heart Surgery - WBC count predicts long-term mortality after percutaneous coronary intervention

Heart Transplantation - Post-transplant strongyloides hyperinfection syndrome reported

Hematopoiesis - Appropriate cell cycle control required for maintaining normal hematopoiesis

Hematopoiesis - Definitive hematopoiesis requires mixed-lineage leukemia gene

Hepatitis B Vaccine - Hepatitis B antigen-pulsed dendritic cells effective in humans

Hepatitis B Virus - Three cis-acting elements needed for efficient plus-strand HBV DNA synthesis

Hepatitis C Virus - Hepatitis C virus co-infection does not alter HIV disease progression

Herpesvirus - Raf promotes HHV8 infection and modulates Kaposi sarcoma pathogenesis

Immunology - CD99 interacts with Mycoplasma hyorhinis ligand

Immunology - Corticosteroids affect viability of murine epidermal Langerhans cells

Immunology - Immunity against infections and vaccines reviewed

Immunology - Integrase inhibitors and cellular immunity suppress retroviral replication

Immunology - Keratinocyte-targeted IL-15 overexpression enhances cutaneous immunity

Immunology - Lactoglobulin conjugation with oligosaccharides reduces immungenicity

Immunology - Retinal transduction does not generate immune tolerance to transgene products

Immunology - Rituximab-mediated depletion of healthy B cells elucidated

Immunology - Specific CTL priming achieved in mouse neonates exposed to spleen cells

Immunology - Therapeutic targeting of CD18 integrins to exclude homing holds promise

Immunology - Transcription factor expression during T-cell maturation clarified

Immunology - Virus-specific T cell response doesn't endure after hepatitis C therapy

Inflammatory Bowel Disease - IBD-related anemia can be successfully treated with iron sucrose, erythropoietin

Inflammatory Mechanism - Annexin expression observed in inflammatory myopathies

Influenza - Company produces further pandemic-like influenza vaccines for NIH studies

Kidney Transplantation - Novel preconditioning regimen enables renal transplants without splenectomy

Lymphoma - Researchers uncover secrets of immune system's munitions factory

Malaria Vaccine -  Plasmodium growth factor-like motifs needed for erythrocyte invasion

Monoclonal Antibody Therapy - Mono- and bi-specific anti-CD33 x anti-CD64 antibodies inhibit AML cell growth

Multiple Sclerosis - Epitope spread predicts disease in model of multiple sclerosis

Multiple Sclerosis - Study sheds light on estrogen's benefit for MS

Myasthenia Gravis - Study compares MuSK antibody-positive and -negative myasthenic patients

Mycobacterium - Phylogeny of M. avium strains inferred from GPL biosynthesis pathway genes

Natural Products - Natural products and related compounds from marine sources are in trials

Non-Hodgkin Lymphoma - Asthma may increase non-Hodgkin lymphoma risk associated with pesticide exposure

Nutrition - Back-to-school means back to germs

Nutritional Supplements - Vitamin E benefits upper respiratory immune function in elderly, study shows

Obesity - Data reveals striking increase in disability claims related to obesity

Oncology - Pharma industry increasingly in-licenses nontraditional source macromolecules

Pain Therapy - Profile of palliative care in Germany examined from survey

Pancreatic Cancer - Additional data from phase I trial of GVAX pancreatic cancer vaccine reported

Pancreatitis - Monoclonal antibody CD 11b ameliorates pancreatic inflammation

Parapertussis -  Bordetella parapertussis strains in Poland characterized

Peritonitis Vaccine -  Salmonella protein coupled to Vi antigen protects against peritonitis

Personnel - Kenneth J. Bloom, MD, becomes medical director of cancer-diagnostics company

Pertussis Vaccine - Acellular pertussis booster induces humoral immunity in adolescents

Pertussis Vaccine - Antibody decay after acellular pertussis vaccine determined

Pharmaceutical & Drug Development - Glycyrrhizic acid conjugates demonstrate anti-HIV and anti-HSV-1 activity

Prion Disease - Immunoprecipitation of prion protein mediated by antibodies

Prostate Cancer - Study shows improved 3-year biochemical control of recurrent prostate cancer

Protease Inhibitors - Serine protease inhibitor 2A inhibits caspase-independent cell death

Receptor Studies - Novel inducible adhesion family GPCR identified in endothelial cells

Renal Cell Carcinoma - FDA grants fast-track status to temsirolimus

Reproductive Medicine - O-linked carbohydrate likely present in male reproductive tract CD52

Respiratory Medicine - HLA-DP mediates beryllium-induced TNF-alpha production by CD4 cells

Rheumatoid Arthritis - Researchers identify mechanism underlying inflammatory joint disease

Rheumatology - Spondyloarthropathy shows chromosomal linkage at 9q31-34

Rotavirus Vaccine - VP7 gene phylogenetic sequence lineage 1 rotavirus better for vaccines

SARS Coronavirus - Niclosamide inhibits severe acute respiratory syndrome coronavirus replication

SARS Risk Factor - Human leukocyte antigens linked to SARS susceptibility and resistance

SARS Vaccine - Distribution of coronavirus and putative receptor determined

Schistosomiasis - Schistosome proteins play roles in host-parasite interactions

Scleroderma - Cu/Zn is a novel autoantibody, could inhibit scleroderma

Sezary Syndrome - CD158k marker may be useful in diagnosis and follow-up of Sezary syndrome

Solid Organ Transplantation - Rituximab does not disrupt ex vivo T-cell responses

Sports Medicine - Early diagnosis of viral skin infections in athletes prevents outbreaks

Stem Cell Research - CD8-deplted donor cell infusions effective for treatment of SCT relapse

Stem Cell Research - Gene expression changes in course of neural progenitor cell differentiation

Stem Cell Research - Mesenchymal stem cells feasible for intervertebral disc regeneration

Stem Cell Research - Myelomonocytic cells sufficient for therapeutic cell fusion in liver

Stem Cell Research - No correlation between apoptosis and growth of myelodysplastic BM progenitors

Stem Cell Research - Stem cell plasticity is a true characteristic of neural stem cells

Stem Cell Transplantation - Dermal multipotent cell transplant treats combined radiation and wound injury

Stem Cell Transplantation - High-dose therapy and autologous SCT for MM poorly responsive to initial therapy

Stem Cell Transplantation - Success of stem cell therapy in ALS will depend a lot on preclinical evidence

Stem Cell Transplantation - Umbilical cord blood feasible alternative source of cells for SCT

Streptococcal Vaccine - Group B streptococcal conjugate vaccine effective in older adults

Systemic Lupus Erythematosus - Prestara clinical trial GL02-01 for women with lupus is complete

Tissue Engineering - Photocrosslinkable hyaluronan scaffold developed for articular cartilage repair

Toxoplasmosis - Sterile immunity against toxoplasmosis in rats investigated

Trypanosomiasis - TNF linked to fetal mortality in Trypanosoma-infected mice

Tuberculosis - Simpler treatment schedules and newer drugs needed to combat TB in Africa

Tuberculosis - Universal measures to control TB in resource-poor countries inappropriate

Tuberculosis Vaccine -  M. tuberculosis and M. bovis BCG induce equal protection

Typhoid Fever Vaccine - Profile of travelers needing typhoid fever vaccination reported

Typhoid Vaccine - Immune responses to oral typhoid vaccine strain reported

Vaccine Adjuvant - HSP60 induces self-tolerance to repeated HSP60 stimulation

Vaccine Delivery - Cholera toxin bile-salt-stabilized vesicles for oral vaccines developed

Vaccine Development - Bacterial genomes pave the way to novel vaccines

Vaccine Development - Ovalbumin incorporated into ISCOMs by lipid film hydration method

Viral Genotyping - A web-based resource identifies genotypes of HIV/HCV/HBV sequences

Wound Care - Anticoagulants may be helpful in wound healing after major surgery

Wound Healing - Surface peptidase expressed during wound healing is a tumor suppressor