Neurogenesis
Alproate promotes ERK pathway-dependent cortical neuronal growth/neurogenesis
Published in Immunotherapy Weekly, October 13th, 2004
"Manic-depressive illness has been conceptualized as a neurochemical illness. However, brain imaging and postmortem studies reveal gray-matter reductions, as well as neuronal and glial atrophy and loss in discrete brain regions of manic-depressive patients," wrote researchers in the United States.
"The roles of such cerebral morphological deficits in the neuropathophysiology and therapeutic mechanisms of manic-depressive illness are unknown. Valproate (2-propylpentanoate) is a commonly used mood stabilizer. The ERK (extracellular signal-regulated kinase) pathway is...
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Source: Immunotherapy Weekly (2004-10-13)
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