Cancer Vaccine
Vaccinia virus expressing lymphoid chemokine elicits antitumor response
Published in Immunotherapy Weekly, October 13th, 2004
According to recent research published in the journal Vaccine, "Secondary lymphoid chemokine (SLC) attracts mature dendritic cells (DCs) and naive T cells. Co-localization of these cells within local tumor environments may enhance the induction of tumor-specific T cells. However, the presence of danger signals or other DC maturation signals are required to optimize T-cell priming. We hypothesized that expression of SLC in vaccinia virus would provide local chemokine delivery and adjuvant factors. A recombinant vaccinia...
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Source: Immunotherapy Weekly (2004-10-13)
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