Streptococcus Vaccine
Sialic acid O-acetylation in group B Streptococcus characterized
Published in Immunotherapy Weekly, October 13th, 2004
"Group B Streptococcus (GBS) is the leading cause of human neonatal sepsis and meningitis. The GBS capsular polysaccharide is a major virulence factor and the active principle of vaccines in phase II trials. All GBS capsules have a terminal alpha2-3-linked sialic acid [N-acetylneuraminic acid (Neu5Ac)], which interferes with complement-mediated killing. We show here that some of the Neu5Ac residues of the GBS type III capsule are O-acetylated at carbon position 7, 8, or 9, a major modification evidently missed in previous studies," researchers in the United States...
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Source: Immunotherapy Weekly (2004-10-13)
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