Immunotherapy Weekly

HIV/AIDS-Associated Insulin Resistance - Novel insulin receptor activator prevents PI-induced insulin resistance

HIV/AIDS-Associated Lymphoma - T- and B-cell lymphoma demographics/immunology in HIV-infection characterized

Hantavirus - Hantavirus outbreak in Brazil via occupational exposure to infected rodents

Head and Neck Cancer - Immunological aspects of head and neck cancer reviewed

Head and Neck Cancer - Nitric oxide accelerates regression in head and neck cancer

Hemorrhagic Fever - Crimean-Congo hemorrhagic fever virus outbreak in Turkey confirmed by testing

Hepatitis - Biotechnology company names clinical advisory board

Hepatitis B Vaccine - Hepatitis B vaccination effective in intravenous drug users

Hepatitis B Vaccine - Practical difficulties in managing hepatitis B in Asia-Pacific reported

Herpesvirus - (S)-MCT prodrug inhibits HSV-1 TK-transduced osteosarcoma cell growth

Herpesvirus Vaccine - Herpesvirus induces IFN-alpha via Toll-like receptor pathways

Human Coronavirus - Coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae

Human Papillomavirus Vaccine - DNA vaccine targeting HPV type 16 oncoprotein E6 developed

Hypertension Vaccine - Vaccine elicits anti-angiotensin I antibodies in hypertensive subjects

Immune Activation - Monocyte activation differs between leprosy and TB in terms of IL-12 secretion

Immunology - C5a receptor essential for optimal generation of antiviral CD8+ T cell response

Immunology - Company initiates phase III clinical trial for FavId

Immunology - CpG DNA-mediated immune response may counteract pulmonary gene therapy

Immunology - E2 drives materno-fetal tolerance by expanding regulatory T cell compartment

Immunology - Gene transfer makes T-cell tolerance to transgene products possible

Immunology - Novel mAbs used to elucidate T-cell RANKL expression

Immunology - TaqMan RT-PCR assay sensitive/specific for respiratory syncytial virus detection

Immunology - Tonsillar tissue cultures preserve their structure for a limited time

Immunology - Trafficking of anti-complement receptor antibody investigated

Immunology - gp120/gp120 mAB/CCL5/CL12 do not alter DC activation and maturation processes

Immunotherapy - FDA accepts sBLA for expanded use of BEXXAR; decision expected by January 2005

Infection Control - Tissue bank to provide sterile soft tissue allografts using gamma irradiation

Infectious Disease - Immunological effects of Rho GTPase degradation by CNF1 clarified

Influenza - Association launches flu-shot locator

Influenza - Influenza A virus outbreak in Israel infected primarily neonates and infants

Influenza - Vaccines are first line of defense for flu prevention, antivirals can play role

Influenza Vaccine - Virus-immunoglobulin complexes involved in early virus elimination

Influenza Virus - Active NF-kappa B signaling is prerequisite for influenza infection

Information Technology - Web-based software for analysis, reporting on raw DNA microarrays available

Irritable Bowel Syndrome - Trial appears to validate finger-stick food-intolerance test

JC Virus - JC virus agnoprotein inhibits DNA repair after DNA damage

Kaposi Sarcoma-Associated Herpesvirus - KSHV ORF57 protein interacts with REF protein and acts as RNA export factor

Keratoacanthoma - Telomerase activity and COX-2 may be potential markers for certain cancers

Leishmania - Chemokines play key role in Leishmania infections; scientists seek a model

Leishmaniasis Therapy - Macrophage-specific drug delivery for leishmaniasis developed

Leishmaniasis Vaccine - Current status of leishmaniasis vaccine development reviewed

Leishmaniasis Vaccine - Progress in vaccine research for visceral leishmaniasis reviewed

Leukemia Vaccine - Leukemia-derived dendritic cells become cells that stimulate T cells

Lung Cancer Vaccine - Peptides eliciting multiple responses in lung cancer identified

Lung Tumors - TTF-1 expression is specific for lung primary in typical and atypical carcinoids

Lymphoma Vaccine - EBNA1-specific CD4+ T cells are key for control of Burkitt lymphoma

Malaria - Inflammatory cytokines increased in pregnant women with P. falciparum

Melanoma - U.S. FDA authorizes start of phase 2 clinical trial on melanoma vaccine

Melanoma Vaccine - Immune responses to peptide epitope in melanoma patients described

Meningococcal Disease - FDA panel recommends licensure of Menactra vaccine

Mesothelioma - Diffuse malignant mesothelioma of the peritoneum and pleura studied

Microbial Genomics - HLP gene expression in C. glabrata may play a role in hemolysin production

Microbial Resistance - Potent beta-lactam selection possible through integron-mediated resistance

Microencapsulation - Encapsulated oral enterotoxigenic E. coli vaccine developed

Microencapsulation - Microspheres induce adult-like CD8+ cytotoxic T cell responses

Microencapsulation - pH-triggered microparticles for peptide vaccination developed

Monoclonal Antibodies - Monoclonal antibodies and therapeutics reviewed

Mucosal Immunization - Effect of particle size on transport across nasal mucosa studied

Nosocomial Infections - FDA grants Aurexis fast track designation

Opportunistic Infection -  P. carinii CBK1 gene may function in signaling pathways for cell growth/mating

Oral Cancer - Saliva plays role in development of oral cancer

Pain Management - Survey finds only 6% of adults recognize symptoms of nerve pain

Pain Management - ThermaCare launches heat wrap for knee pain

Pain Management - Understand your prescription painkillers, advises foundation report

Patents - Companies win patents supporting Alzheimer disease immunotherapy treatments

Personnel - Deborah Jorn, Stephen Farrand named to new posts at science-based drug company

Personnel - Edmund Mickunas named VP regulatory and clinical affairs

Polio Vaccine - Simian virus-tainted polio vaccine does not raise childhood cancer risk

Product Licensing - U.S. FDA grants tentative approval for generic antihistamine HCL tablets

Prognostics - Prognostic markers determined for renal failure severity in PUUV infection

Prostate Cancer - Trial to assess if Zyflamend prevents prostate cancer

Prostate Cancer Vaccine - Antigen-derived peptides induce CTLs in prostate cancer patients

Prostate Cancer Vaccine - DNA vaccine elicits immune response in patients with prostate cancer

Prostate Cancer Vaccine - Gene-based therapy in prostate cancer reviewed

Protein Signaling - Structural differences identified in transmembrane of mouse, human NKG2D

Proteomics - Novel assay facilitates analysis of NK cell microsomal proteins

Psoriasis - Enrollment completed for phase II trial for Psoraxine

Psoriasis - Marketing authorization for psoriasis drug granted by European Commission

Pulmonary Tuberculosis - Late diagnosis of pulmonary tuberculosis led to community outbreak

Respiratory Syncytial Virus - Recombinant respiratory syncytial viruses characterized

Respiratory Syncytial Virus - V beta 14+ T cells mediate disease induced by RSV G glycoprotein

Retinal Regeneration - First derivation of retinal cells from embryonic stem cells; may treat blindness

Retrovirus - NC structural interactions with other Gag domains necessary for Psi RNA binding

Retrovirus - Retroviruses spread by induction of virological synapses

SARS Coronavirus - Pivotal role of SARS coronavirus E protein in viral budding elucidated

Smallpox - FDA clinical hold for ACAM2000 removed, BLA submission planned

Stem Cell Research - CCR7 expression on BM-derived dendritic cells is indication of cell maturity

Stem Cell Research - Model transforms stem cells to express breast cancer estrogen receptor

Stem Cell Research - NIH grants new money for more research into Alzheimer, spinal cord injuries

Stem Cell Research - Nestin expression lost in neural stem cells through proteasome/Notch signaling

Stem Cell Research - Neural progenitor cell lines inhibit tumor growth

Stem Cell Research - Neural stem cells improve sensorimotor deficits in brains with focal ischemia

Stem Cell Research - Newly generated neurons evidenced in the olfactory bulb

Stem Cell Research - Notch signaling important for primitive to definitive neural SC differentiation

Stem Cell Research - PGE2 produced by COX-2 increases BMP-2 expression via binding the EP4 receptor

Stem Cell Research - STAT6 deficiency increases bone marrow-committed myeloid progenitors

Stem Cell Research - Skin-derived stem cells differentiate into neural lineages

Stem Cell Research - Slow-dividing fraction of SCs may be associated with primitive function

Stem Cell Research - Stem cells have potential to regenerate damaged inner ear

Streptococcus Vaccine - Group A Streptococcus strains causing epidemics analyzed

Thrombocytopenia - Low-molecular-weight and unfractionated heparins contraindicated in HIT patients

Tissue Engineering - Engineered chondrocytes reconstruct fibrocartilage zone at bone-tendon junction

Transplant Medicine - Genetic signatures profile kidney transplant rejection status

Transplant Medicine - Metabolite assays detect 6-mercaptopurine toxicity after liver transplantation

Tuberculosis - CDC funding to be used for development of TB vaccine trial sites in India

Tuberculosis Vaccine - DNA vaccine activates CD8+ cells and reduces lung injury in TB

Vaccine Adjuvant - Coding sequence optimization enhances enterotoxin expression in tobacco

Vaccine Development - Antigen injection into anterior chamber activates splenic CD8+ cells

Vaccine Efficacy - Effect of freezing rate and excipient on vaccine infectivity compared

Vaccine Efficacy - Pseudovirus encoding IL-2 restores immune responses to vaccines

Vaccine Vector - Modified vaccinia virus induces moderate activation of dendritic cells

Vasculitis - Antiviral therapy helps manage polyarteritis nodosa in hepatitis B patients

West Nile Virus - Recovery at 1 year is poor in elderly persons with West Nile virus infection

West Nile Virus - West Nile virus spread rapidly throughout the U.S.