Gastrointestinal Disease
Interleukin-10 gene therapy ameliorates colitis in murine models
Published in Immunotherapy Weekly, October 20th, 2004
According to published research from England, "the transfer of genes encoding immunoregulatory proteins is a promising new strategy in the treatment of intestinal inflammation. Previous work has demonstrated that daily systemic interleukin (IL)-10 therapy is able to prevent disease onset in animal models of colitis but is not sufficient to treat established disease. This study investigates the therapeutic efficacy of an adenovirus encoding IL-10 (AdvmuIL-10) in the treatment of experimental colitis."
"Colitis was induced in BALB/c mice by the addition of dextran sodium sulfate to the...
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Source: Immunotherapy Weekly (2004-10-20)
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