Immunotherapy Weekly
Susan Hasty, Publisher
Table of Contents . . . October 27th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Immunotherapy Weekly | Other Publications
Allergy & Immunology - S. aureus protein A induces airway inflammatory response by TNFRI activation
Arthritis - Env-pX transgene in bone marrow cells play a role in arthritis severity
Arthritis Therapy - Lactobacillus GG bacteria ameliorate arthritis in Lewis rats
Autoimmune Disease Therapy - Adalimumab effective against severe psoriasis and psoriatic arthritis
Immunology - vIRF3 regulates immune system and apoptosis via NF-kappaB activity inhibition
AIDS/HIV Vaccine - HIV cholera toxin fusion gene expressed in transgenic potato
AIDS/HIV Vaccine - Pathogenic SHIVs and SIVs target different CD4+ T cell subsets
Adenovirus - Nosocomial infections in Japan caused by new adenovirus type 4 genomic variant
Allergies - New food intolerance, complex carbohydrate intolerance, identified
Allergy Medicine - Allergens play important role in the immunopathogenesis of AEDS
Antimicrobial Susceptibility - Real-time PCR detects A. phagocytophilum susceptibility to antimicrobials
Apoptosis - P63 and p73 not required for development and p53-dependent apoptosis of T cells
Arthritis - Pharma company issues statement on withdraw of Vioxx
Arthritis - Topical anti-arthritic safer than pills with same active ingredient, study shows
Asthma - Application filed with U.S. FDA for childhood asthma incentive spacer
Asthma - Cutting household allergen levels unlikely to have much impact on asthma
Asthma - Hospital emergency admissions are linked to exposure to urban pollutants
Atrophic Gastritis - Genetics/lifestyle influence protective effect for developing atrophic gastritis
Autoimmune Autonomic Neuropathy - Passive transfer of autoimmune autonomic neuropathy demonstrated
Bacterial Resistance - Salmonellae acquire antimicrobial resistance independent of selection pressure
Bioterrorism - Management of laboratory exposures to bioterrorism agents reported
Biowarfare - Management guide for lab exposure to bioterrorism agents released
Bladder Cancer - Bladder cancer bank will be effective tool in marker development
Brain Cancer - IFN-alpha transfected dendritic cells enhance antitumor efficacy
Brain Cancer - Temozolomide well tolerated in patients with primary CNS lymphomas
Breast Cancer - Biotech company wins award from National Institute of Standards and Technology
Breast Cancer - Generex Biotechnology establishes CRADA
Breast Cancer - Genomic testing identifies chromosomal changes in sporadic breast cancer
Business Update - Biopharmaceutical company collaborates with Kissei on YSCMA project
Business Update - Blansett Pharmacal to promote Naprelan to U.S. physicians
Cancer Research - Study questions link between SV40 and pleural mesothelioma
Cancer Therapy - Data presented on 1D09C3 anticancer monoclonal antibody at conference
Cancer Therapy - NIH grant to be used for dendritic cell-based cancer vaccines
Cancer Vaccine - Activation of immunity by double-stranded RNA promotes antitumor activity
Cancer Vaccine - Adenoviruses encoding CD40L or IL-2 effective against B cell lymphoma
Cancer Vaccine - Luteinizing hormone-releasing hormone multimer characterized
Cancer Vaccine - Metalloproteinase modulates fibromatosis size and cell invasiveness
Cancer Vaccine - Totally synthetic vaccine targeting epithelial tumors developed
Chemotherapy - Imatinib mesylate inhibits T-cell growth and delayed-type hypersensitivity
Chemotherapy - PEI regimen active/well tolerated for sensitive relapsed small-cell lung cancer
Chronic Fatigue Syndrome - Chronic fatigue rates dipped after September 11 attacks
Chronic Hepatitis C - Hepatitis C virus infection does not stimulate hepatic interferon production
Collaborations - CombinatoRx and partner initiate brain cancer collaboration
Congenital Heart Block - Study recommends anti-SSA/SSB antibody screening for pregnant women
Cord Blood - Umbilical cord blood transplant after nonmyeloablative conditioning is promising
Cystic Fibrosis - Pharma company announces results from phase II trial of Bronchitol
Cytomegalovirus - Phase 1 clinical trial for cytomegalovirus gene encoded vaccine initiated
DNA Repair - Cadmium inhibits DNA mismatch repair
Decontamination - Surface sampling/QPCR analysis effective for decontamination strategy evaluation
Diabetes - Health department awarded grant to impact obesity, diabetes and asthma
Diabetes Pathogenesis - Autoimmune conditions share overlapping genetically controlled pathways
Diagnostics - FDA clears Duet System for automated FISH scanning of amniotic cells
Diagnostics - Methods for detection of Enterocytozoon bienuesi in stool specimens compared
Diagnostics - Novel PCR assay useful for rapid detection of emetic Bacillus cereus
Diagnostics - Quantitative real-time PCR useful for diagnosis of ocular toxoplasmosis
Diagnostics - Rapid real-time PCR detects/quantitates M. avium subspecies in contaminated milk
Diagnostics - Real-time PCR used to quantitate uncultured bacteria in central Baltic Sea
Diagnostics - Repeated fanolesomab injections not linked to adverse effects
Diagnostics - Seminested PCR-enzyme immunoassay is favorable method for candidemia diagnosis
Diagnostics - UG52-UC53 and 292-222 primer pairs most appropriate for Echovirus detection
Diarrhea - Probiotics may address antibiotic-associated chronic diarrhea
Drug Delivery - Genelabs lupus drug fails trial
Drug Development - Inhibitor design wraps packing defects in HIV-1 proteins
Drug Development - Research and development company receives grant from NIH
Emergency Preparedness - Emergency plans needed in event of bioterrorism or natural epidemic
Enzymology - Process to purify Bacillus circulans chitinase A1 developed
Epstein-Barr Virus - LMP1 expression induces hyperactivation of B lymphocytes
Finance - ProMune maker raises $25 million in private financing
Fitness & Wellness - Whole Foods baker's dilemma leads to new gluten-free product line
Food Allergies - FAAN launches Trick or Treat for Food Allergy Halloween Coin Collection Program
Food Science - Immunoenzymic method provides simple, precise determination of histamine in food
Foodborne Pathogens - Pathogenic enteric viruses persist in marinated mussels despite acid conditions
Foot-and-Mouth Disease - Sequence variability described in foot-and-mouth disease virus
Friend Retrovirus - Virus-neutralizing antibodies essential for Friend retrovirus immunity
Fungal Research - Gene essential for A. fumigatus growth but does not contribute to pathogenicity
Fungal Toxin - Fumonisins detected in herbal tea and medicinal plants in Turkey
Gastric Cancer - EBV-gastric carcinoma pathogenesis different in intestinal or diffuse EBV-GC
Gastroenterology - PAR2 alters colonic permeability via IFN-gamma pathways
Gene Therapy - Break repair protein endo-exonuclease is a therapeutic target for cancer
Genomics - Short tandem repeat analysis monitors chimerism following bone marrow transplant
Graft-Versus-Host Disease - Denileukin diftitox tolerable and active in steroid-refractory acute GVHD
Graft-Versus-Host Disease - Donor CD8+ T cell-mediated TAA-specific antitumor response driven by GVHD
HIV-1 - Publication demonstrates that anti-integrase agents block viral replication
HIV/AIDS Immunology - CD25+/CD4+ cells associated with favorable clinical markers of HIV status
HIV/AIDS Immunology - Immune activation set point is established early in HIV infection
HIV/AIDS Prevention - Australian company to lead NIH-funded project to prevent HIV, other STDs
HIV/AIDS Research - APOBEC3F properties/hypermutation preferences indicate activity against HIV-1
HIV/AIDS Research - Drug boosts HIV-1-specific lymphocyte activity in infected patients, study shows
HIV/AIDS Research - Fibronectin fragments stimulate transendothelial migration of HIV-1-infected MNL
HIV/AIDS Research - HIV-1 and MLV Gag sufficient to recruit APOBEC3G into virus-like particles
HIV/AIDS Research - HIV-1 gp120 decreases NO-dependent cyclic GMP accumulation in brain astroglia
HIV/AIDS Research - LAMPS of M. fermentans/M. penetrans activate HIV LTR through Toll-like receptors
HIV/AIDS Research - Mutations alter capsid protein assembly rate without changing monomer stability
HIV/AIDS Therapy - Drug-resistant HIV mutants higher in PBMC than plasma after changes in ART
HIV/AIDS Therapy - HIV phenotypic/genotypic markers of resistance evaluated at virologic failure
HIV/AIDS Therapy - New HIV technologies alter the nature of HIV medicine materially and socially
HIV/AIDS Therapy - Novel anti-HIV drug candidate targets CD4 lymphocytes
HIV/AIDS Therapy - Race is not associated with pharmacokinetics of nevirapine
HIV/AIDS Therapy - d4T treatment enhances mitochondrial oxidative stress
HIV/AIDS-Associated Infection - CD8+ T cells specific for EBV/CMV/FLU activated during primary HIV infection
Healthcare Costs - Michigan physician groups join insurance company to utilize incentive program
Heart Disease - ANG II activates effectors of mTOR via PI3-K signaling in heart muscle
Heart Transplant - NIH grant to be used for heart preservation research
Helicobacter Pylori - H. pylori RpoB polymorphism correlates with differential induction of IL-8
Helicobacter Pylori - Helicobacter pylori virulence genes are associated with peptic ulcer disease
Hematopoiesis - Hematopoietic cells and osteoblasts derived from common BM progenitor cell
Hepatitis C Vaccine Adjuvant - Novel cytokines induce hepatitis C virus-specific cyotoxic T cells
Herpesvirus - vGPCR target gene expression drastically curtailed by host shutoff
Hookworm Vaccine - Enzyme cascade of hemoglobin proteolysis hookworm intestine described
Human T Cell Leukemia Virus - Expression of CCL5/RANTES elevated in adult T-cell leukemia cells
Immunological Diseases - MedImmune granted exclusive license to proprietary TIRC7 program
Immunology - Analysis of Na+, K+-ATPase beta 2 subunit reported
Immunology - California immunology researchers identify T cell that relieves asthma in mice
Immunology - Induction through privileged site needs sympathetic nervous system
Immunology - Natural toxin induces preferential and prolonged deletion of innate-like B cells
Immunology - Several immunotoxins demonstrate anticancer activity in clinical trials
Immunology - Washington state cord blood program announces hospital partner
Influenza - Adults over age 65 encouraged to "Beat Both Bugs" this fall
Influenza - After flu exposure, mild exercise protects mature mice from dying
Influenza - Carrington sub gets $6M biodefense grant to develop nasal flu vaccine
Japanese Encephalitis - Viral infection block interferon-induced Jak-Stat signaling pathway
Kidney Transplantation - Basiliximab safe and effective as induction therapy
Leptospirosis - Dominant leptospire genotype associated with outbreak clusters in India
Leukemia Therapy - High-dose cytosine arabinoside/etoposide + TBI feasible in HSCT for ALL
Licensing Agreement - Abbott enters drug-discovery agreement
Listeria Outbreak - L. monocytogenes infectivity in farm animals may be associated with subtypes
Liver Regeneration - Fluidized bed bioreactor has potential for extracorporeal liver supply
Lung Cancer - Company preparing phase II study of cancer vaccine
Lung Cancer - FDA grants fast track status for L-BLP25 liposome cancer vaccine
Lung Cancer - Myotubularin-related protein suppresses growth of lung carcinoma cells
Lupus - Genes linked to SLE disease activity identified
Lupus Erythematosus - Prednisolone, other immunosuppressants studied in treatment of lupus
Lymphoma - Lymphoma risk does not rise with chronic exposure to 50 Hz magnetic fields
Malaria Vaccine - Aotus monkey cytokines quantified by real-time quantitative RT-PCR
Malaria Vaccine - Plasmodium EBA-175 sequences that bind to erythrocytes identified
Malaria Vaccine - Antibodies to Plasmodium MSP119 form ring structures with antigen
Measles Virus - Attachment sites for measles virus receptors overlap on globular head
Melanoma Research - Mutated BRAF (V599E) is an attractive molecular target for melanoma treatment
Melioidosis Vaccine - Burkholderia pseudomallei secretion mutant had attenuated virulence
Mesothelioma - High proportion of mesothelioma in South Africa from asbestos exposure
Metabolism - Is interleukin-6 the "Holy Grail" of exercise mediation?
Microbial Resistance - Fluoroquinolone use predicts rates of resistant Pseudomonas aeruginosa
Monkeypox Virus - Real-time assay to detect monkeypox virus in rodents developed
Mycobacterium Infection - Macrolide-containing regimens 55% successful in MAC lung disease
Myocarditis Therapy - Blocking macrophage migration inhibitory factor improves myocarditis
Neutropenia - G-CSF does not improve morbidity/mortality in febrile neutropenia
Newcastle Disease Vaccine - Virosome and ISCOM vaccines protect against Newcastle disease
Non-Hodgkin Lymphoma - Allogeneic blood transfusion does not increase risk of non-Hodgkin lymphoma
Norovirus - Ethanol and bleach insufficiently inactivate norovirus model
Noscomial Infection - Hospital-acquired C. difficile infection 1300-fold higher than in community
Nutrition - Nutritional products company testifies dietary supplements reduce costs
Oncology Research - Constant light exposure increases cancer incidence and decreases lifespan
Osteoporosis - Phase II trial data released on twice-yearly injection therapy
Parasitic Infection - Furamidine analog markedly potentiates activity against T. cruzi/L. amazonensis
Parasitic Infection - Smoker airflow obstruction severity correlates with Pneumocystis colonization
Parasitic Infection - ap65 gene silencing reduces vaginal epithelial cells adherence by T. vaginalis
Patents - Additional patent issued for use of product to treat respiratory papillomatosis
Patents - Biotechnology company and C.R. Bard Inc. settle patent infringement suit
Patents - Company files U.S. patent application for new class of antibacterial agent
Patents - Patent issued on new OTC cold and flu formulation
Patient Safety - Merck withdraws Vioxx based on 3-year data from APPROVe clinical trial
Pediatric Pneumonia - Oral amoxicillin/parenteral penicillin equal in children with severe pneumonia
Peptide Generation - Cathepsin S appears to play important role in generating peptides
Personnel - Jane Green named VP, corporate communications of immune-focused company
Personnel - Nobel laureate and DNA pioneer Maurice Wilkins dies at 88
Personnel - William S. Reardon appointed to board of small-molecule drug development firm
Polyomavirus Simian Virus - Genetic variation in polyomavirus simian virus 40 identified
Product Licensing - Company inks exclusive European license agreement for Olux
Product Licensing - License application submitted for HIV-1 and hepatitis C, B screening assay
Product licensing - Company licenses DNA-based respiratory health product to Allergy Research Group
Prostate Cancer - Androgen receptor associates with epidermal growth factor receptor
Prostate Cancer - Antioxidants block prostate cancer in transgenic mice
Prostate Cancer - Neuroendocrine differentiation evaluation recommended in prostate cancer
Prostate Cancer - Novel immunotoxin shows promise in murine model
Proteomics - Nobel Prize in chemistry goes to pair of Israeli researchers and an American
Protozoal Disease - cAMP signaling in kinetoplastid protozoa useful target for antiparasitic drugs
Psoriasis - Company seeks to begin proof of concept study for ATL1101 in psoriasis
Psoriasis - European Commission approves ENBREL for treatment of psoriasis
Psoriasis - Non-approvable letter issued for oral tazarotene
Respiratory Syncytial Virus - Infectious nontransmissible respiratory syncytial virus developed
Retrovirus Research - TRIM5 alpha mediates postentry block to N-tropic murine leukemia viruses
Rheumatoid Arthritis - Current smokers with a classic genetic risk factor at higher risk for RA
Rheumatoid Arthritis - FDA approves ENBREL to induce major clinical response in patients with RA
Rheumatoid Arthritis - FDA approves REMICADE regimen as first-line therapy in patients with RA
Rheumatoid Arthritis - Researchers focus on new rheumatoid arthritis diagnosis, management strategies
Rotavirus - Hospital discharge data useful for monitoring vaccine program effects
Rubella Vaccine - Enhanced vaccination program disrupts rubella transmission in Spain
Salmonella Vaccine - IgA antibodies to O and H antigens protect mice against Salmonella
Sexually Transmitted Disease - Sexually transmitted infections are an issue for travelers
Smallpox - Second U.S. contract awarded for smallpox vaccine
Stem Cell Research - CD56-expressing cells appear to contain multipotential stem cells
Stem Cell Research - Gene expression profiles analyzed during CD4+ T cell differentiation
Stem Cell Research - Lung side population cells are derived from the bone marrow
Stem Cell Research - PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny
Stem Cell Research - TGF-beta 1 stimulates matrix metalloproteinase production by corneal cells
Stem Cell Research - Transplanted CNS cells survive/migrate/differentiate in ischemic cerebral cortex
Stem Cell Transplantation - Allogeneic HSCT induces remission of severe and refractory rheumatoid arthritis
Stem Cell Transplantation - Early CNS complications follow reduced-intensity stem cell transplantation
Stem Cell Transplantation - Stem-cell transplants may be used to repair peripheral nervous system
Stomach Cancer - Protein kinase C theta may be novel therapeutic target for GI stromal tumors
Streptococcus Vaccine - Streptococcus dysgalactiae proteins protect against bovine mastitis
Streptococcus Vaccine - Macroglobulin-GRAB binding mediated by charged motifs in Delta A region
Systemic Lupus Erythematosus - Active SLE complicates pregnancy
Tetanus Toxin - C-terminal domain of tetanus heavy chain rescues neurons from apoptosis
Tissue Engineering - Chondrocyte expansion on matrix monolayers does not prevent dedifferentiation
Tissue Storage - CordLife opens second tissue processing and storage facility in Singapore
Transplant Medicine - Cytokine-modified dendritic cells are unable to prevent graft rejection
Tumor Suppressor Gene - TES is the best candidate tumor suppressor gene at chromosome arm 7q31
Type 1 Diabetes - NIH funds centers to study islet transplantation
Vaccine Development - Immunogenic antigens of eel pathogen Vibrio vulnificus identified
Vaccine Vector - Nonpathogenic, live, viral vaccine vectors responses characterized
Vaccinia Virus Vaccine - Vaccinia virus and complement protein interaction kinetics described
Vector-Borne Pathogens - Concurrent infections with vector-borne pathogens caused fatal hemolytic anemia
Veterans Healthcare - U.S. Senate candidate proposes expanded veteran benefits
Virology - JC virus genotypes 3 and 7 identified in South African patients
Virology - RNA viruses alter vector host range, resulting in potential disease emergence
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