Immunotherapy Weekly

Influenza - Thirty million doses of influenza vaccine shipped to healthcare providers

Influenza - U.S. health services department releases statement regarding Chiron flu vaccine

Influenza Vaccine - Effect of influenza vaccination on primary care contact rates studied

Influenza Vaccine - Hospital visit prevention by influenza vaccine during pregnancy studied

Influenza Vaccine - Study of influenza virus A M2 peptide conjugate vaccines conducted

Influenza Virus - Antigenically and genetically similar influenza C viruses in Japan characterized

Influenza Virus - Influenza B virus lacks sequence homology to influenza A virus antigenic sites

Ischemia/Reperfusion - SOD2/3 shows promise for treatment of mesenteric I/R injury

Legal Issues - Maker of skin lightening creams responds to TV statement on product dangers

Lentivirus - LEDGF/p75 is a component of functional lentiviral preintegration complexes

Leptospirosis - Unique Leptospira strain isolated from patient with pulmonary hemorrhage

Liver Cancer - Estrogen plays a critical role in female hepatocarcinogenesis

Liver Necrosis - Plasma osteopontin levels rise in patients diagnosed with fulminant hepatitis

Lung Cancer - Laser-induced thermotherapy effective in lung metastases and primary lung tumors

Lyme Arthritis - Treatment with anti-neutrophil mAb hastens development in mice

Lymphoma - T cells needed early in ASCT to induce a graft-versus-lymphoma effect

Lymphoma Therapy - Cytostatic drugs enhance antitumor activity of anti-CD30 antibody

MMR Vaccine - MMR vaccination not associated with developmental disorders

Malaria Vaccine - Antibodies to P. vivax protein studied in malaria-exposed subjects

Malaria Vaccine - Incidence of severe malaria useful as endpoint for vaccine trials

Malaria Vaccine - Molecular analysis of antibody response to malaria sporozoite reported

Malaria Vaccine - Quantitative PCR used to test vaccines in human experimental malaria

Malignant Meningioma - Expression of cytokeratin by malignant meningiomas can be a diagnostic pitfall

Melanoma - B-RAF is therapeutic target in melanoma

Melanoma Vaccine - Dendritic cell vaccine boosts T cell-mediated immunity to tyrosinase

Meningitis Outbreak - Nosocomial meningitis outbreak caused by Acinetobacter baumannii

Meningitis Vaccine - PorA-specific differences found in antibody avidity after Men B vaccine

Meningococcal Disease - Domestic clones of N. meningitidis circulated in meningococcal disease outbreak

Meningococcal Vaccine - People often infected have poor immune response to Neisseria vaccine

Muscle Regeneration - BM-derived SP/Mac-1^low cells play an important role in muscle regeneration

Mutagenesis - Novel method assesses DNA damage after exposure to benzo(a)pyrene

Myasthenia Gravis - HLA haplotypes associated with myasthenia gravis

Mycobacterium Haemocanis -  M. haemocanis infection prevalence higher in kennel-raised than pet dogs

Myelodysplastic Syndrome - Telomere dynamics is prognostic factor for assessment of AML risk in MDS patient

Oncology - Cancer research company receives grant to study cell-based cancer vaccine

Oncology - FDA grants fast-track designation for metastatic melanoma treatment

Oral Mucositis - Company announces clinical progress with CG53135 for oral mucositis

Oral Squamous Cell Carcinoma - TNF-alpha/soluble receptors ratios prognostic in oral squamous cell carcinoma

Osteoarthritis - Investigational therapy for bone loss increased bone mineral density

Osteoporosis - Novel semiannual therapy may prove effective in bone resorption

Osteoporosis - SERM+ teriparatide offers improved bone therapy for postmenopausal patients

Osteosarcoma - Trichostatin A offers novel therapeutic strategy for osteosarcoma

Papillomatosis - Omomyc expression in the skin prevents Myc-induced papillomatosis

Parainfluenza Virus - Sendai virus vaccine is safe and immunogenic in healthy adults

Personnel - Biopharmaceutical company announces appointment to board of directors

Personnel - Dr. Eric von Hofe named VP for product development and scientific affairs

Personnel - Dr. Udo Klein named SVP of chemical genetics-based drug development company

Personnel - Pharma company focusing on bone loss appoints CEO

Pertussis Vaccine - Computer simulations of strategies for pertussis vaccination developed

Pharmacology - CYP2C19 mutations regulate interactions between lansoprazole and tacrolimus

Polio Vaccine - Polio vaccines containing simian virus 40 may cause human cancer

Poxvirus Vaccine - Structural proteomics of the poxvirus family reviewed

Prescription Drugs - VIOXX prescription refunds offered by Minneapolis-based retail store

Product Licensing - Life sciences company, Rubicon Genomics sign genome amplification agreement

Prostate Cancer - Micelle delivery of doxorubicin increases cytotoxicity to prostate cancer cells

Prostate Cancer - Novel antitumor agents block intracellular protein kinase B/Akt activation

Protein Precursor - Transferrin receptor 2 protein not expressed in normal erythroid cells

Protein Signal - Dok/SHIP/Grb2 key intermediates in regulating antigen-induced mediator release

Protein Signal - Novel repressor of NF-kappa B-inducing kinase suppresses NF-kappa B activation

Proteomics - Protein binding sites attractive drug target for TCL1 protein-caused leukemia

Proteomics - Proteomic and genetic technologies characterize cis double mutant

Psoriasis - NK cell activating gene associated with susceptibility to psoriasis vulgaris

Receptor Studies - Saccharide-directed delivery to biological receptors optimized

Renal Carcinomas - XIAP expression is a new independent prognostic marker in clear-cell RCCs

Respiratory Diseases - IL-17 upregulates hBD-2 in airway epithelium

Respiratory Syncytial Virus - HLA-DP4 presents immunodominant peptide from RSV G protein to T cells

Rheumatology - Shortage of pediatric rheumatologists can lead to substandard care

Rubella Vaccine - Rubella immunization and postpartum care reviewed

SARS Coronavirus - Highly infectious SARS-CoV reveals cell tropism/receptor expression correlation

SARS Infection Control - Providing SARS infection control information to outpatients increases compliance

SARS Vaccine - Antibody responses against SARS-coronavirus studied in SARS patients

Salmonella Outbreak -  Salmonella outbreak traced to unshelled peanuts originating from one country

Sinusitis Vaccine -  Haemophilus membrane protein and cholera toxin induce mucosal immunity

Smallpox - FDA fast track status granted for modified vaccinia ankara program

Smallpox - U.S. HHS awards $232 million in biodefense contracts for vaccine development

Smallpox Research - California scientists help bring study of smallpox virus into 'molecular age'

Smallpox Vaccine - Positive side effects of smallpox vaccination described

Sphingolipidoses - Sphingolipidoses are relatively common and important health problem in Turkey

Squamous Cell Carcinoma - hCAP18(109-135) may be useful antitumor therapeutic agent for oral SCC

Stem Cell Research - G-CSF augments 1,25-dihydroxyvitamin D-3-induced monocytic differentiation

Stem Cell Research - Harvard researchers seek OK to produce cloned human embryos

Stem Cell Research - IFN-gamma promotes neuronal differentiation and neurite outgrowth of neural SCs

Stem Cell Research - IV neural SCs migrate to injured spinal cord and differentiate into neural cells

Stem Cell Research - New report evaluates importance of cell therapy

Stem Cell Research - Survey shows 3 in 4 Americans support Nancy Reagan's call for stem cell research

Stem Cell Research - c-Kit receptor identified as regulator of adult neural stem cells in the eye

Stem Cell Transplantation - De novo testosterone produced following transplantation of Leydig stem cells

Stem Cell Transplantation - Donor lymphocyte infusions induce graft-versus-myeloma effect after ASCT rescue

Stem Cell Transplantation - Methotrexate associated with improved overall survival following ASCT

Stem Cell Transplantation - Pre-allogeneic SCT is not associated with increased hypercoagulability

Stem Cell Transplantation - Telomere length predicts neutrophil recovery in G-CSF absence after ASCT

Stem Cell Transplantation - Topical and systemic dermal stem cell transplant accelerates skin wound healing

Stem-Cell Transplantation - Daclizumab increases GVHD mortality when combined with steroids

Swine Dysentery -  Brachyspira hyodysenteriae lipoprotein protects pigs from dysentery

Swine Fever Virus - Optimized protocol developed for detection of classical swine fever virus

Systemic Lupus Erythematosus - Mycophenolate mofetil is effective for managing non-renal lupus

Systemic Lupus Erythematosus - Oral contraceptive use doesn't cause disease flare in patients with SLE

Systemic Lupus Erythematosus - Oral contraceptives, IUD produce same risk of disease flares in women with SLE

Systemic Lupus Erythematosus - Preliminary results of Prestara trial on BMD in women with lupus not positive

Systemic Lupus Erythematosus - Therapeutic target discovered for potential rheumatic disease treatment

Tamoxifen - MPT-independent pathway suggested for tamoxifen-induced apoptosis

Tissue Engineering - Scaffold topography alters cardiomyocyte network intracellular calcium dynamics

Toxoplasmosis - Toxoplasmosis reported during pregnancy in immunocompetent woman

Transplant Medicine - Placental blood cell transplant feasible in children with sickle cell disease

Tuberculosis Vaccine - "M. tuberculosis-induced IFN-gamma expression lower in TB patients

Tuberculosis Vaccine -  M. tuberculosis antigen structures confirm binding orientation

Tuberculosis Vaccine - BCG heat-shock proteins protect against tuberculosis challenge

Tumorigenesis - IKK beta links inflammation and tumorigenesis in colitis-associated cancer

Type 1 Diabetes - CTLA4 may be a susceptibility gene for type 1 diabetes

Usutu Virus - Pathology/viral distribution characterized in fatal usutu virus infection

Vaccine Adjuvant - Aluminum hydroxide adjuvant induces macrophage differentiation

Vaccine Adjuvant - CPG 7909 allows lower dose of Fluarix influenza vaccine

Vaccine Adjuvant - Cholera toxin subunit enhances efficacy of DPT vaccine

Vaccine Adjuvant - Very small size proteoliposomes are effective vaccine adjuvants

Vaccine Development -  Vibrio cholerae proteinases characterized

Vaccine Development - Active immunization against cytokines demonstrated

Vaccine Development - Cyclooxygenase-2 is target for disorders of skin and oral cavity

Vaccine Development - HSP70 domains stimulate cytokines and chemokines

Vaccine Safety - Pneumococcal and influenza vaccines can be administered simultaneously

Vaccine Safety - Use of vaccines in pregnancy reviewed

Vaccine Vector - Adenoviral vector carrying type 35 fiber is promising vaccine vehicle

Vaccines - Study finds demand for vaccines in U.S. will increase 8.6% annually

Viral Hepatitis - Hepatitis B superinfection cannot restore hepatitis C-specific CD8 reactivity

Virology - Poxvirus protein N1L inhibits NF-kappa B and IRF3 signaling

Virology Vaccine - Interfering vaccine converts virulent infection into immunizing one

Virology Vaccine - PRRSV vaccine did not affect virus shedding in PRRSV-infected pigs

Women's Health - U.S. National Cancer Institute discusses risks of breast implants