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Vaccine Development

Cyclooxygenase-2 is target for disorders of skin and oral cavity

Published in Immunotherapy Weekly, November 3rd, 2004

Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity.

According to a study from Japan, "Anti-cancer effects of cyclooxygenase (COX)-2 inhibitors have been reported, but not fully investigated in skin and oral diseases. 5-Aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) for treating those patients with skin and oral lesions is a highly sophisticated procedure, but the incidence of disease recurrence after treatment is rather significant."

"To confirm that COX-2 could be a molecular target in adjunctive therapy to ALA-based PDT, we investigated:...

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