Published in Immunotherapy Weekly, December 1st, 2004
"Poliovirus is heat-labile; on heating at 50 degrees C for 30 minutes its infectivity decreases drastically and its antigenicity reverts from N to H. However, mutants resistant to heating at 50 degrees C for 30 minutes from the Sabin 1 and 2 viruses were isolated by repeating the process of incubation of the virus stock at 50 degrees C for 30 minutes and multiplication of the remaining virus in a cell culture. The isolated mutants were stable genetically, and maintained the rct and d markers of the parent virus," scientists in Japan report.
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