Immunotherapy Weekly

Hematopoiesis - M-CSF essential for proliferation/differentiation of BM-derived stromal cells

Hemophilia B - Major genes share the control of factor IX antibody expression

Hepatitis C Virus - Obtaining maximum information about hepatitis C quasispecies discussed

Hepatitis C Virus - U.S. FDA approves Pegasys and Copegus as hepatitis C treatment for HIV patients

Herpesvirus - TAP degradation studied, role of a herpesvirus revealed

Histochemistry - Neuregulin receptor plays key role in cardiac, skeletal muscle

Human Herpesvirus-8 Infection - Sociological risk factors determined for HHV8 infection in cancer patients

Human Papillomavirus - Subsequent HPV risk in HIV+ women not lowered by natural infection

Human Papillomavirus Vaccines - Findings in human papillomavirus vaccines provide new insights

Immunology - Autoantigen recognition in encephalomyelitis studied, role of T cell motif shown

Immunology - CD8+ T cell responses during encephalomyelitis studied, aspects clarified

Immunology - Lipopolysaccharide response in Drosophila studied, negative crosstalk revealed

Immunology - MHC class I heavy chains examined, independent competitions revealed

Immunology - Macrophage chemotaxis studied, immunoregulatory role evident

Immunotherapy - Cobra inks deal to supply trial material for TNFa Kinoid

Immunotherapy - IL-7 and IL-15 studied as possible treatment for immunodeficiency

Immunotherapy - Technology yields novel immunotherapeutic protein platform

Infectious Diseases - Data demonstrate therapeutic benefit of expanded myeloid progenitors

Inflammatory Bowel Disease - New treatment offers hope for Crohn, ulcerative colitis

Influenza Vaccine - Economic analysis of annual influenza vaccination of children reported

Influenza Vaccine - Epitope analysis for influenza vaccine design reported

Influenza Vaccine - Fluvirin vaccine license reinstated by U.K. regulatory agency

Kawasaki Disease - Adrenomedullin is overexpressed in blood monocytes in acute KD

Lead Poisoning - Lead isotopic measurements in feces match levels in household dust

Leishmaniasis Vaccine -  Leishmania membrane proteins are prophylactic against leishmaniasis

Leishmaniasis Vaccine - Drug-sensitive Leishmania vaccine developed

Leptospirosis Outbreaks - Morbidity/mortality decreased among children pre-exposed to leptospires

Leukemia - Gamida-Cell, Teva to develop and commercialize StemEx for leukemia

Leukemia - Small cell variant of T-cell prolymphocytic leukemia diagnosed

Listeria Monocytogenes - Low prevalence of Listeria monocytogenes in humans

Liver Cancer - Researchers detail new studies and findings in the area of liver cancer

Lung Cancer - Physical activity may reduce lung cancer risk among those with high exposure

Lupus - Monoclonal anti-idiotype to anti-ribosomal P antibodies developed

Lupus Nephritis - Half million Americans will develop lupus-related kidney disease, experts say

Lymphoma - Eradication of Helicobacter pylori affected the ongoing mutation of IgH

MMR Vaccine - Policies on MMR vaccinations must balance freedoms and responsibilities

MMR Vaccine - Respiratory delivery of MMR vaccine more immunogenic than injection

Macrophages - cAMP-mediated macrophage inhibition studied, protein roles clarified

Malaria Infection -  Plasmodium protein proteolytically processed during cell invasion

Malaria Vaccine -  Plasmodium merozoite surface protein protects against malaria

Malaria Vaccine - Allele specificity of antibody responses against P. falciparum outlined

Malaria Vaccine - Parasite growth rates measured in volunteers challenged with malaria

Malaria Vaccine - Vaccines with DNA and viral vectors possess differential immunogenicity

Malaria Vaccines - Researchers report details of new studies and findings in the area of malaria vaccines

Marketing - DTC spend soars, as consumers find ads increasingly believable and likeable

Measles Epidemiology - Measles virus isolated in Croatia during outbreak characterized

Melanoma - Decreased Apaf-1 expression with melanoma progression may up chemo resistance

Melanoma Vaccine - Mimotope immunization elicits specific antibody response to Mel-CAM

Meningitis Vaccine - Antibodies to polysaccharide of Neisseria meningitidis analyzed

Meningococcal Vaccine - Meningococcal polysaccharide-protein conjugate vaccines reviewed

Mesothelioma - Diagnostics company launches blood test for mesothelioma

Mesothelioma Vaccine - Fowlpox vector expressing proteins is active against mesothelioma

Metabolic Syndrome - Short-term very-low-carbohydrate diets improve metabolic abnormalities

Multidrug Resistance Gene - Linkage disequilibrium/haplotype architecture determined for ABCC1 & ABCG2 genes

Multiple Sclerosis - Multiple sclerosis microarray studies with RPI-78M analysis completed

Multiple Sclerosis Vaccine - Phase 2 study on safety, dosing of vaccine for multiple sclerosis announced

Myeloid Leukemia Vaccine - Chronic myeloid leukemia vaccine improves molecular remission rate, data show

Neisseria Epidemiology - Risk of N. meningitidis high in travelers to Hajj in Saudi Arabia

Neisseria meningitides - Repetitive-PCR distinguishes N. meningitidis outbreak-related strains

Neural Stem Cell Research - SDF-1alpha/CXC4 pathway directs neural stem cell migration to CNS injury sites

Neurogenesis - Several factors influence the physiological neurogenesis process

Neuroscience - Treatment of systemic diseases is required to alleviate movement disorders

Newcastle Disease Vaccine - Immunogenicity of Newcastle disease vaccines in chickens compared

Obesity - High-fat diet alters homeostatic regulation of energy balance

Obesity - Obesity increases risk for metabolic and cardiovascular disease

Obesity - Therapeutic targets for obesity-associated diabetes based on inflammation link

Oncogenesis - Cancer, type 2 diabetes, and aging reviewed

Oncology - Data advance knowledge in oncology research

Oncology - Ep-CAM-specific monoclonal antibody MT201 slashes breast cancer cell growth

Oncology - Hepatitis B virus X protein may play a role in liver cancer formation

Osteoarthritis - Combination gene therapy heals cartilage

Ovarian Cancer - PPARgamma implicated in the onset and development of ovarian cancer

Pain Medicine - D3 receptor stimulation promotes proliferation of post-natal SVZ-derived cells

Pancreatic Cancer Vaccine - MUC1 vaccine with SB-AS2 adjuvant is safe in pancreatic cancer patients

Parkinson Disease - Establishing a symptomatic preclinical threshold may help evaluate PD therapies

Pediatric Glioma - Oncoscience AG reports response rate of 35.3% in pediatric glioma trials

Pediatric Vaccines - Cost of child immunization services in urban Bangladesh reported

Peptide Receptor - Anchor profiles of HLA-specific peptides presented

Periodontal Disease - Galectin-9 expression is inflammatory response to P. gingivalis LPS

Personnel - Clinical trial adds member to scientific board

Personnel - International biotechnology company appoints new CEO

Pharmaceutical Research - Scientists' findings show regulation of immune cell memory

Physiology - Regulation of glucocorticoid studied, role of hydroxysteroid dehydrogenase shown

Pneumococcal Vaccine - Pneumococcal polysaccharide mimotope induces protective response

Pneumococcal Vaccine - Self-reported pneumococcal vaccination validated through local agencies

Pneumococcal Vaccines - Research add new data to pneumococcal vaccines body of knowledge

Polio Vaccine - Dendritic cells and macrophages are productively infected by poliovirus

Polio Vaccine - Immunization schedules affect excretion of polio vaccine strains

Polio Vaccine - Seroprevalence of poliovirus antibody in northern Greece reported

Porcine Epidemic Diarrhea Virus - Competitive blocking ELISA detects porcine epidemic diarrhea virus in feces

Prion Disease - Trapping prion protein in endoplasmic reticulum impairs maturation

Probiotics - Guidelines are important in developing and using probiotics

Prostate Cancer - HPV DNA found in prostate tissue suggests role in prostate cancer

Proteomics - Angiostatin staunches inflammation by suppressing leukocyte recruitment

Proteomics - Brain amyloid beta protein level analyzed, antibody effect revealed

Proteomics - New findings in the area of proteomics detailed

Pseudomonas Aeruginosa - Multilocus sequence typing used for genetic analysis of P. aeruginosa

Rabies Vaccine - Rabies prophylaxis in malnourished children provides protection

Recurrent Pregnancy Loss - TNF blockade may be therapeutic for antiphospholipid syndrome complications

Renal Failure - Nutrition therapy must be closely monitored in patients with acute renal failure

Rheumatic Heart Disease - Patients with rheumatic heart disease have a higher frequency of ACE II genotype

Rheumatoid Arthritis - Biotech company announces phase 2 study of rheumatoid arthritis treatment

Rheumatology - The COX-2 inhibitor DFU regulates VEGF expression in rheumatoid synovial cells

Rotavirus Epidemiology - Epidemiology of rotavirus G-types circulating in Hong Kong is changing

Rotavirus Vaccine - Distribution of rotavirus serotypes has implications for vaccines

SARS - Multiple factors increase risk of developing SARS in health care workers

SARS - Researchers publish new studies and findings in the area of SARS

SARS Coronavirus - SARS coronavirus detected in lungs by RT-PCR following death from SARS

SARS Coronavirus - SARS coronavirus more stable than human coronavirus HcoV-229E in lab conditions

Salmonella Vaccine - Overexpression of Salmonella proteins induces CD4 and CD8 T cells

Salmonellosis Outbreak - Salmonellosis outbreak associated with rare phage type of S. enteritidis

Sexually Transmitted Infection - Exploring sexual networks yields insights into sexually transmitted infections

Smallpox Vaccine - Neutralizing anti-vaccinia antibodies titration method standardized

Smallpox Vaccine - Poxvirus CD8+ T cell determinants aid smallpox vaccine design

Stem Cell Research - Biology of stem cells not fully understood

Stem Cell Research - High affinity leptin receptors found in MSCs from control & osteoporotic donors

Stem Cell Research - Intermediate-type stem cells may be instrumental in tumor genesis and growth

Stem Cell Research - Molecular pathways regulating HSC self-renewal not fully understood

Stem Cell Transplantation - Amniotic-membrane and limbic stem cell transplantation treats ocular burns

Stomach Cancer - Allelic distribution of STRs correlates with different gastrointestinal tumors

Streptococcus Vaccine - C-polysaccharide in Streptococcus pneumoniae vaccines characterized

Streptococcus Vaccine - Immunity to Streptococcus pneumoniae mediated by MyD88

Streptococcus Vaccines - Studies add new findings to streptococcus vaccines body of knowledge

Syphilis - Syphilis rates increasing around the world

Syphilis Epidemic - Syphilis epidemics in U.S. have unforced oscillations every 8-11 years

Tapasin - Tapasin examined, role of charged amino acid in MHC function shown

Theileriosis Vaccine - Timing of live theileriosis vaccine is critical for efficacy

Tissue Development - Lysyl oxidase-like proteins have a role in mouse development

Tissue Engineering - Cardiac cells self organize into contractile 3-dimensional cardiac tissue

Tissue Engineering - Extracellular matrix component distribution of engineered cartilage determined

Tissue Engineering - Surgisis collagen mesh useful alternative for tissue replacement in pediatrics

Tissue Engineering - Synchronous contractions induced in cardiac tissue engineered constructs

Toxoplasma Gondii - Anti-Toxoplasma gondii antibodies detected in patients with neoplasia

Transdermal Drug Delivery - Efficacy of topical emedastine formulations evaluated

Transplant Medicine - Case highlights the potential multifactorial pathogenesis of cytopenias

Transplant Medicine - Decreased cytomegalovirus reported after antilymphocyte therapy

Transplant Medicine - Ganciclovir delays cytomegalovirus infection in renal transplant recipients

Transplant Medicine - Nationwide matching program for paired kidney exchange outlined

Transplant Medicine - New findings in the area of transplant medicine described

Tuberculosis Vaccine - BCG vaccine protects neonatal calves against M. bovis challenge

Tuberculosis Vaccine - Early BCG vaccination elicits adult-like immune response in calves

Tuberculosis Vaccines - New research in the area of tuberculosis vaccines detailed

Umbilical Cord Blood - Cord blood banking regulated in the EU to assure safety/efficacy

Umbilical Cord Blood - Cord stem cells may replace embryonic stem cells for tissue therapy in future

Vaccine Adjuvant - Natural endogenous adjuvants reviewed

Vaccine Adjuvant - Subcutaneous injection of IL-12 induces systemic inflammatory responses

Vaccine Development - Ethics of mandatory childhood immunizations discussed

Vaccine Development - IL-15-independent antiviral function of CD8+ T cells outlined

Vaccine Development - In vivo induced antigen technology reviewed

Vaccine Development - Oral vaccination with biodegradable particulates reviewed

Vaccine Development - Tiered pricing of vaccines is not subsidy

Vaccine Development - Vaccination practices in U.S. emergency departments reviewed

Vaccine Efficacy - Shifts in global immunization goals from 1984 to 2004 reviewed

Vaccine Safety - Pediatric vaccines exert divergent effects on female and male mortality

Vaccine Safety - Thimerosal neurotoxicity associated with glutathione depletion

Vaccines Development - Researchers provide details of new studies and findings in the area of vaccines development

Varicella-Zoster Virus - Polymorphisms to distinguish varicella-zoster virus strains evaluated

Virology - Efavirenz-related K103N mutation may not be detected by standard genotyping

Virology - La Crosse virus protein counteracts effects of short interfering RNA

Virology Vaccine - Mucosal immunization induces IgG/IgA responses in CD4+-deficient mice

Virus Contamination - PCR is an alternative to MAP tests for the detection of viral contaminants

West Nile Encephalitis Vaccine - Live measles vaccine expressing protects against West Nile encephalitis