Hemophilia B
Major genes share the control of factor IX antibody expression
Published in Immunotherapy Weekly, March 30th, 2005
According to researchers in the United States, "we tested the hypothesis that the antibody response to human factor IX in mice is controlled by genetic factors, especially histocompatibility antigens. Seven inbred mouse strains were immunized against human factor IX by adenoviral gene transfer or serial injections of human factor IX protein. A/J mice had the highest antibody response and 2 C57 mouse strains had the lowest response."
"We used the adenovirus vector to immunize 26 recombinant inbred mouse strains (AXB and BXA) derived from AM and C57BL/6J mice and observed highly...
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Source: Immunotherapy Weekly (2005-03-30)
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