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Immunotherapy Weekly

Susan Hasty, Publisher

Table of Contents . . . April 6th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Immunotherapy Weekly | Other Publications

Allergy and Immunology - Eosinophils in human blood stimulate angiogenesis

Immunology - B-cell development is affected by noninherited maternal antigens

Liver Cancer - MAGE-A10- and SSX-2-specific CD8+ responses in liver cancer characterized

Lymphoma - Investigation of CD3+/HLA-DR+ activated T cells may aid prognostics

Prostate Cancer Vaccine - Dendritic cell vaccine rescues peripheral T cell tolerance in prostate cancer

Acinetobacter Infection - Risk factors identified for multidrug-resistant A. baumannii infection

Acute Leukemia - Liposomal amphotericin B safe and effective for fungal infection treatment

Acute Myeloid Leukemia - Ceplene receives orphan drug designation in Europe for AML

Acute Myeloid Leukemia - Gemtuzumab ozogamicin suitable for first-line therapy in elderly patients

Adverse Drug Reaction - Rituximab ameliorates interferon-related thrombocytopenia

Air Monitoring - PCR method quantifies A. fumigatus conidia from environmental air samples

Cancer Therapy - Researchers describe findings in cancer therapy studies

Allergy Medicine - New findings in the area of allergy medicine detailed

Allergy and Immunology - Asthma relapse in children is common, possible risk factors identified

Allergy and Immunology - FDA approves CLARINEX-D 24 hour

Allergy and Immunology - Genetic make-up determines immune-inflammatory response after burn injury

Allergy and Immunology - Immunomodulatory therapy for chronic hepatitis B prevents liver complications

Allergy and Immunology - RNA transcripts are targets for asthma therapy

Cancer Therapy - Studies advance knowledge in cancer therapy research

Alzheimer Disease - Cerebral hemorrhage dependent on antibody recognition of amyloid beta

Anthrax Vaccines - Reports advance knowledge in anthrax vaccines research

Antigen Presentation - MHC survival and activation examined, influence of antigen presentation revealed

Antimicrobial Resistance - Carbapenem resistance is emerging in strains worldwide

Apoptosis - Pro-apoptotic protein dehydrogenase activity studied, consequences revealed

Cancer Vaccines - Studies describe new findings in cancer vaccines research

Arthritis - Collagen-induced arthritis studied, effect of inhibitor revealed

Asthma - Company signs second asthma feasibility study deal in 3 months

Asthma - Interleukin-5 controls UGRP-1 during allergic airway inflammation

Asthma Vaccine - Vaccine protects against B. pertussis exacerbation of allergic asthma

Avian Influenza - Cross-impact analysis predicts mutation trends in influenza A

Bioartificial Liver - Bioreactor developed that supports bioartificial liver

Diagnostics - Studies add new findings to diagnostics body of knowledge

Bioartificial Liver - Collagen/chitosan/heparin improves hepatic tissue engineering biocompatibility

Biological Activity -  Plasmodium falciparum erythrocyte binding studied, specificity revealed

Biomedical Engineering - Company dedicates expanded kinase screening facility in Dundee, Scotland

Biotechnology - Microencapsulation of living cells in covalently linked membranes reported

Bioterrorism - U.S. NIAID $15 million contract awarded to develop three monoclonal antibodies

Bone Marrow Research - Bone marrow cells engraft within epidermis and proliferate without cell fusion

Immunology - Studies describe new findings in immunology research

Borna Disease - Orf virus protects against Borna disease virus infection of the brain

Bovine Viral Diarrhea Virus - Genome analysis of live bovine viral diarrhea virus vaccine conducted

Brain Cancer - Therapy against protein kinase C cedes little relief to glioma patients

Breast Cancer Therapy - Arg-482 not essential for transporting antibiotics, bile acids, and sterols

Breast Cancer Vaccine - DNA vaccine inhibits breast cancer in mice through induction of autoimmunity

Business & Finance - Anti-infectives-focused drug company reports fourth quarter 2004 results

Malaria Vaccines - Researchers describe findings in malaria vaccines studies

Business & Finance - Biopharma company announces financial results

Business & Finance - Pharma company reports year-end operating results, product candidates progress

Business & Finance - Therapeutics company reports financial results, provides clinical update

Business Update - Biotherapeutics company announces strategic updates at investment meeting

Business Update - Company gets 2 biodefense contracts totaling $4.8 million

Business Update - Pharma companies enter agreement for deorphanization of a series of proteases

Oncology - Reports add new data to oncology research

Business Update - Pharmaceutical company updates Novartis peptide deformylase inhibitor program

Cancer Immunotherapy - CpG oligodeoxynucleotides activate tumor-specific immune responses

Cancer Metastasis - Genetically engineered mice capture the essence of invasive prostate cancer

Cancer Models - Cell lineage-specific complementation of Rb used to refine cancer models

Cancer Therapy - Adenovirus-delivered anti-Tie-2 intrabody shuts down tumor angiogenesis

Cancer Therapy - DHMEQ targets the nuclear factor kappaB pathway to fight cancer

Oncology - Research in oncology provides new insights

Cancer Therapy - Data advance knowledge in cancer therapy research

Cancer Therapy - Dose optimization enables rapamycin to suppress tumor angiogenesis

Cancer Therapy - Doxazosin halts vascular endothelial cell adhesion, migration, and invasion

Cancer Therapy - Liposomal encapsulation augments systemic efficacy of aphidicolin

Cancer Therapy - Rituximab effective for radiation-relapsing primary cutaneous B-cell lymphoma

Oncology - Studies add new findings to oncology body of knowledge

Cancer Vaccine - Blockade of B7-H1 and PD-1 by antibodies potentiates cancer immunity

Cancer Vaccine - DNA vaccination against tumors reviewed

Cancer Vaccine - DNA vaccine encoding genetic fusion of CEA and GM-CSF developed

Cancer Vaccine - Imatinib mesylate overcomes tumor-induced CD4+ T-cell tolerance

Cancer Vaccine - Impact of p53-based immunization on chemically-induced tumors investigated

Oncology - Studies advance knowledge in oncology research

Cancer Vaccine - Role of exosomes in cancer-associated T-cell signaling defects investigated

Cancer Vaccines - Reports describe recent advances in cancer vaccines research

Cell Biology - Select signaling pathways could be targeted for breast cancer inhibition

Chagas Disease Vaccine - Oral immunization with Phytomonas serpens protects against Trypanosoma

Chlamydia Vaccine - Immunology of Chlamydia infection aids Chlamydia vaccine design

Tuberculosis Vaccines - Recent findings in tuberculosis vaccines described

Cholera Monitoring - Monitoring environment and cholera presence predicts diarrhea epidemics

Chronic Lymphocytic Leukemia -  FCGR3A/2A polymorphisms may not affect response to alemtuzumab

Clinical Trials - Enrollment of phase 2 clinical trial of antibody for treatment of HIV complete

Colon Cancer - Gene replacement therapy suppresses colorectal tumors in animal models

Complementary and Alternative Medicine - Wine and tea polyphenols treat human ailments by diminishing new vessel growth

Cowpox - Cowpox virus infection associated with streptococcal septicemia

Virology - Researchers' findings advance virology research

Crimean-Congo Hemorrhagic Fever - ELISA method used to diagnose Crimean-Congo hemorrhagic fever

Cystic Fibrosis - Persistent environmental reservoirs of P. aeruginosa not found in CF center

Cytomegalovirus Vaccine - Cytomegalovirus DNA vaccine protects against murine cytomegalovirus challenge

Dendritic Cell Vaccine - CD70 induction on dendritic cells promotes CD8+ T cell responses

Dengue Hemorrhagic Fever - Dengue hemorrhagic fever increasing among children in northern Brazil

Dengue Virus - Effect of DEN-2 infection on macrophage gene expression determined

Dermatology - Eighteen cases of severe bullous skin disease analyzed in a burns unit

Dermatology - Recent findings in dermatology described

Diabetes Diagnosis - IA-2A and GADA measurement aids diagnosis and prognosis of type 1 diabetes

Diabetes Type 1 - Diabetes type 1 outbreak earlier in immigrants' children born in Italy

Diagnostic Imaging - Contrast-enhanced ultrasonography discerns the vascularity of liver tumors

Diagnostics - Clearview ULTRA FOB now available

Diagnostics - Reports advance knowledge in diagnostics research

Diarrheal Illness - Hygiene interventions identified to reduce diarrhea in less developed countries

Dilated Cardiomyopathy - Dilated cardiomyopathy requires immunohistochemical and molecular investigation

Drug Delivery - Copolymer-conjugates localize to tumor vessels

Drug Development - Study shows cisplatan treatment unhindered by drug for drug-induced hearing loss

Drug Metabolism - UGT isoforms involved in mycophenolic acid glucuronidation identified

Embryonic Stem Cell Research - Cell-surface marker found on embryonic hepatoblasts

Embryonic Stem Cell Research - Embryonic stem cell differentiation evaluated in different culture conditions

Embryonic Stem Cell Research - Enforced PU.1 expression rescues osteoclastogenesis from ESCs lacking Tal-1

Embryonic Stem Cell Research - Repository stores embryonic stem cell lines with genetic disorders

Embryonic Stem Cell Research - Stably transfected ESC clones maintain self-renewal and pluripotency

Enzymology - Angiogenesis and phospholipase A2 alpha correlate in human colorectal cancer

Enzymology - Recent findings in enzymology described

Equine Infectious Anemia Virus - Specificity of antibodies induced by equine infectious anemia virus reported

Exercise and Nutrition - Exercise and diet have roles in prevention of chronic disease

Feto-Maternal Tolerance - Heme oxygenase could be therapeutic target in immunological pregnancy problems

Finance - Biotech company receives going concern qualification in FY2004 audit report

Finance - Life science research-focused company reports strong Q4, 2004 financial results

Gastric Cancer - Heparanase expression aligns with gastric carcinoma invasion and metastasis

Gastrointestinal Stromal Cancer - Loss of p16 protein can be used to identify high-risk patients

Genetics & Genomics - IS1- or IS10- activated AcrEF efflux pump may relay AcrAB in serovar Typhimurium

Genome Microarray - Hybrid algorithm optimizes selection of genes for microarray analysis

Genomic Expression - Cytokine allele frequencies differ between racial and ethnic groups

Gingivitis - Bioactive glass ameliorates gingivitis-related inflammation

Glycoprotein Ligands - Th1 binding to ICAM-1 analyzed, glycoprotein-mediated rolling reported

Gynecology - Recent studies add new data to gynecology research

HIV/AIDS Drug Development - Anti-HIV-1 compounds separated via capillary zone electrophoresis

HIV/AIDS Drug Development - PNA-transportan conjugate targeted to HIV-1 TAR is antiviral and virucidal

HIV/AIDS Drug Development - Plant extracts have anti-HIV activity

HIV/AIDS Drug Discovery - HIV-1 integrase inhibitors identified using 3D pharmacophore-guided database

HIV/AIDS Drug Resistance - Drug-resistant HIV-1 genotypes detected only in subjects infected after 2000

HIV/AIDS Drug Resistance - HIV-1 Vif changes associated with development of protease inhibitor resistance

HIV/AIDS Infection - Amphotericin-B reactivates latent HIV-1 infection

HIV/AIDS Lipodystrophy - VLDL elevation in early HAART therapy caused by impaired VLDL clearance

HIV/AIDS MALT Lymphoma - HIV+ MALT lymphoma remission induced by HAART alone

HIV/AIDS Pathogenesis - APOBEC3G polymorphisms not associated with HIV disease progression

HIV/AIDS Pathogenesis - C-terminal domain of HIV-1 integrase is a DNA-binding domain

HIV/AIDS Pathogenesis - Cytoplasmic tail slows HIV-1 Env folding from late prebundle into 6-helix bundle

HIV/AIDS Pathogenesis - Late stage R5 HIV-1 infection induces cytokine and CCR5 expression

HIV/AIDS Pathogenesis - M-tropic HIV-1 activation increases virus load in intestinal mucosa

HIV/AIDS Pathogenesis - Separate HIV Nef domains are required to affect MHC-1 and CD4 cells

HIV/AIDS Pathogenesis - Vpr enhances RANKL production via glucocorticoid receptor activity potentiation

HIV/AIDS Prevention - Appropriate HIV education maximizes acceptance of antenatal HIV antibody test

HIV/AIDS Prognosis - Survival prognostic factors differ by CD4 count among IVDU pre/post HAART era

HIV/AIDS Research - CD4+ cell response differs between HIV-exposed seronegative and HIV+ women

HIV/AIDS Research - MLV RNase H primer grip is an important determinant of fidelity of DNA synthesis

HIV/AIDS Research - Tat methylation by PRMT6 regulates HIV-1 gene expression

HIV/AIDS Screening - Urgent care center-based routine HIV screening programs are effective

HIV/AIDS Therapy - 20 mg/kg of amprenavir twice daily is safe for HIV-infected children

HIV/AIDS Therapy - C/EBP alpha reverses anti-adipogenic effects of nelfinavir

HIV/AIDS Therapy - Encouraging results reported from phase 2 trial of HIV immune-based therapy

HIV/AIDS Therapy - Fixed conformation nucleoside analogs inhibit excision-proficient HIV-1 RT

HIV/AIDS Therapy - HAART leads to normalization of anti-Hsp70 and anti-cholesterol Ab levels

HIV/AIDS Therapy - IL-16 levels increase after structured intermittent HAART interruption

HIV/AIDS Therapy - Researchers' work adds to HIV/AIDS therapy body of knowledge

HIV/AIDS Therapy - Ritonavir does not inhibit calpain

HIV/AIDS Vaccine - Anti-CXCR4 antibodies differ significantly in ability to inhibit HIV entry

HIV/AIDS Vaccine - C-terminal tail of HIV transmembrane glycoprotein involved in cell fusion

HIV/AIDS Vaccine - HIV preclinical interventions in nonhuman primates investigated

HIV/AIDS Vaccine - HIV preventive vaccine trials in developing countries examined

HIV/AIDS Vaccine - Peptide immunogens enhance immune response against HIV mutant strains

HIV/AIDS Vaccine - Poxvirus SIV vaccine partially protects juvenile macaques against SIV

HIV/AIDS Vaccine - Predictive value of primate models for AIDS therapies reviewed

HIV/AIDS Vaccine - Rhabdoviral prime-boost induces strong anti-HIV immune responses

HIV/AIDS Vaccine - Role of IL-7 in pathogenesis and treatment of HIV infection reviewed

HIV/AIDS Vaccine - Targeting CD4i epitope in HIV vaccine design explored

HIV/AIDS Vaccines - Researchers' findings advance HIV/AIDS vaccines research

HIV/AIDS-Associated Lipodystrophy - Subcutaneous fat loss not due to accelerated apoptosis in HIV lipodystrophy

Head and Neck Cancer - Dendritic cells mature in presence of tumor cells from head and neck cancer

Head and Neck Cancer - Interleukin-8 levels rise in patients with progressive squamous cell cancer

Healthcare Coverage - Disease management services launched with Westchester County, New York

Heat Shock Proteins - Heat shock protein 60 examined, specific binding of lipopolysaccharide shown

Hematology - Angiogenic cytokines predict multiple myeloma progression

Hematopoiesis - Recent findings in hematopoiesis provide new insights

Henoch-Schonlein Purpura - Plasmapheresis can quickly resolve cerebral vasculitis in HSP patients

Hereditary Angioedema - Protein therapeutic company recombinant human C1 inhibitor trial approved

Human Papillomavirus - Epitope specificity of vaccine-induced T cell response against HPV18 reported

Human Papillomavirus - HPV-13 polymorphisms determined for HIV+ and women at risk for HIV infection

Human Papillomavirus - New research targets men to study virus that causes cancer in women

Idiopathic Thrombocytopenic Purpura - T-cell apoptosis disrupted in patients with active ITP

Immunology - Activated immunocompetent cells analyzed, differential expression revealed

Immunology - Data advance knowledge in immunology research

Immunology - SLNs displayed greater immune response against cancer than non-SLNs

Immunology - TIM-3 gene polymorphism associated with atopic disease susceptibility

Immunosuppression - Mycophenolate mofetil delays hepatitis C recurrence after liver transplantation

Immunotherapy - Addition of GS doesn't enhance proapoptotic properties of MTX

Immunotherapy - Study shows utility of small-molecule telomerase activators for HIV/AIDS therapy

Infections - Inflammatory and antiviral responses in liver studied, requirements clarified

Influenza - Pharmaceutical company launches new version of its pediatric influenza vaccine

Influenza Vaccine - Acidic polymerase epitope of influenza elicits potent antiviral response

Influenza Vaccine - Approaches to influenza prevention and treatment in travelers reviewed

Influenza Vaccine - Growth of attenuated influenza vaccine strains in cell lines achieved

Influenza Vaccine - Safety and immunogenicity of adenovirus-vectored influenza vaccines reviewed

Influenza Vaccines - Findings describe new data in influenza vaccines research

Innate Immunity - Drosophila peptidoglycan recognition protein acts as an innate immune receptor

Kaposi Sarcoma-Associated Herpesvirus - New findings in the area of kaposi sarcoma-associated herpesvirus described

Kidney Cancer Vaccine - Vaccine elicits diverse CD8+ T-cell responses to renal cell cancer antigens

Kidney Transplantation - Rituximab may prevent acute rejection of B-cell-replete kidney grafts

Leukemia Vaccine - Leukemia vaccines may benefit from immune responses against Wilms tumor WT1

Leukemia Vaccine - Natural killer cell receptor-expressing cells play role in leukemia therapy

Listeria Therapy - CpG oligodeoxynucleotides enhance neonatal resistance to Listeria

Lymphoma Vaccine - Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody

Malaria - ABCA1 gene deletion protects against cerebral malaria in mice

Malaria Vaccine - CD28 in T and B cell responses required for protection against malaria

Malaria Vaccine - Genetic approach to identify immunity targets in malaria parasites developed

Malaria Vaccine - Polymerized d-peptides used for immunizing animals against malaria

Malaria Vaccines - Recent findings illuminate research in malaria vaccines

Mantle Cell Lymphoma - Utility of MCL cell lines as in vitro models evaluated

Measles Vaccine - Impact of population decline on dynamics of measles in Italy explored

Melanoma Vaccine - Gene expression in melanoma metastases and daughter cell lines investigated

Melanoma Vaccine - Hypothesis to explain ability of BCG and vaccinia to treat melanoma presented

Melanoma Vaccine - Melanoma-associated antigen mimotope inhibits melanoma cell growth

Melonoma - Pharma companies announce results of phase I/II study of melonoma treatment

Mergers & Acquisitions - Allergy control company to acquire Allergy Control Products

Mergers & Acquisitions - Shareholders of pharmaceuticals companies approve merger

Mucosal Immunization - Studies describe new findings in mucosal immunization research

Multiple Myeloma - External analyses of multiple myeloma trial announced

Muscular Dystrophy - Cyclosporine A treatment ameliorates symptoms in mice

Myelodysplastic Syndrome - Immunobiologic therapies for myelodysplastic syndrome reviewed

Myeloma Vaccine - Anti-alpha 4 integrin monoclonal antibody inhibits multiple myeloma growth

Myocardial Infarction - Phase 1 myoblast cell transplantation study data presented at cardiology meeting

Nervous System - Nervous system development in normal and atresic chick embryo intestine compared

Neural Embryonic Stem Cell Research - Neuronal differentiation achieved from cultured embryonic germ cells

Neural Stem Cell Research - Antibody microarray correlates cell phenotype with surface marker

Neural Stem Cell Research - Ginsenoside-Rd from Panax notoginseng enhances NSC astrocyte differentiation

Neural Stem Cell Research - NSCs from ESCs relieve symptomatic motor behavior in Parkinson disease model

Neural Stem Cell Research - RB & RB2/p130 genes have overlapping functions during early NSC differentiation

Neural Stem Cell Research - Repeated cytokine administration improves generation of dendritic cells

Neurology - Presence of non-neuronal auto-antibodies failed to provide clinical profile

Neuroscience - Cathepsin B and angiogenesis foster glioma progression

Neuroscience - Findings in neuroscience provide new insights

Norovirus - New data illuminates research in norovirus

Oncogenesis - Orthodenticle homologue 2 is linked to the formation of medulloblastoma

Oncogenesis - Smad4 changes are involved in the formation of cervical cancer

Oncology - Angiogenesis denotes a risk for second primary tumors in oral cancer patients

Oncology - Folate pathway genes influence the pharmacodynamics of leukemia therapy

Oncology - Gene networks reverse breast cancer tumorigenesis after chromosome 8 delivery

Oncology - Granulocyte chemotactic protein-2 bolsters tumor formation

Oncology - Methylation changes in prostate genes may encourage oncogenesis

Oncology - New data illuminates research in oncology

Oncology - Progression-elevated gene-3 promoter selects cancer cells for gene delivery

Oncology - Silencing of imprinted genes linked to cellular stress and tumorigenesis

Oncology - Specific monoclonal antibody for aldo-keto reductase AKR1C3 developed

Oncology - The carboxyl-terminal repressor domain of MBP-1 stops prostate cancer growth

Oncology - The isoflavone genistein uses select molecules to harness angiogenesis

Oncology - The origins of testicular germ cell tumors are poorly understood

Oncology - Tumor location guides the approach of rapamycin against glioma

Oncology - VEGF receptor inhibition impairs mammary tumor growth in mice

Opportunistic Infection - Neutrophil depletion method affects outcome of murine pulmonary aspergillosis

Ovarian Cancer - Peptides from HER-2/neu-overexpressing tumors induce antitumor responses

Pancreatic Cancer - Pancreatic tumors should be profiled before COX-2 inhibitors are initiated

Pathogenic Escherichia coli -  E. coli O157:H7 survival on vegetables dependent on soil compost type

Peptide Fragments - Major histocompatibility class II molecules studied, mechanism clarified

Personnel - Defense contractor hires consultant to develop stem cell research center grant

Personnel - Margaret A. Liu, MD, appointed to board of DNA-focused biosciences company

Pharmaceutical Research - Healthcare, biotech ompanies join forces to conduct cancer biomarker study

Physiology - Lipopeptide and peptidoglycan recognition studied, role of TLR6 clarified

Pneumocystis Infection - Neonatal lungs lack maturation factors for efficient cellular functioning

Polio Vaccines - Researchers' work adds to polio vaccines body of knowledge

Product Licensing - BN ImmunoTherapeutics inlicenses technology for breast cancer vaccine

Product Licensing - Chemicon licenses Quantum Dot antibody reagent line

Prostate Cancer - Earlier use of prostate cancer vaccines urged by Hopkins scientists

Prostate Cancer - Novel gene markers identified through expression microarray analysis

Proteomics - Low molecular weight cyclin E isoforms augment melanoma metastasis

Proteomics - New findings in proteomics described

Psoriasis - Survey shows psoriasis foundation members more aware, satisfied with treatments

Renal Cancer - Antisense oligonucleotide to Ki-67 limits tumor growth but not vessel density

Respiratory Pathogen - Respiratory infection spread during air travel rarely occurs

Rheumatoid Arthritis - Genetics company to conduct genome association study of rheumatoid arthritis

Rotavirus Vaccine - Immunization with rotavirus virus-like particles elicits immune responses

Rotavirus Vaccines - Researchers detail new studies and findings in the area of rotavirus vaccines

SARS - Convalescent plasma therapy shortens hospitalization stays of SARS patients

SARS - Events reconstructed during SARS outbreak in February 2003 in Singapore

SARS - Novel monoclonal antibodies neutralize SARS coronavirus in vitro

SARS - Nursing students more stressed than medical students during SARS outbreak

SARS - SARS seroprevalence rate is low in apparently healthy healthcare workers

SARS Coronavirus - Recombinant nucleocapsid protein-based assay detects anti-SARS-CoV IgG

SARS Prevention - Residents of Taiwan have increased "willingness to pay" to reduce SARS risk

SARS Vaccine - Two neutralizing regions on SARS spike glycoprotein identified

SARS Virus - Hamster is better model than mouse for therapy against SARS virus replication

Salmonellosis Vaccine -  Salmonella pathogenicity island trigger colitis

Salmonellosis Vaccine - Extracts from Salmonella Enteritidis protect against salmonellosis

Schistosomiasis Vaccine - Calpain found in penetration glands of Schistosoma japonicum cercariae

Smallpox Vaccine - Severe headaches common after smallpox vaccination

Sporotrichosis - Sporotrichosis diagnosis may be confounded by Leishmania coinfection

Stem Cell Research - 4-Hydroxynonenal inhibits cell proliferation in fetal liver HSCs

Stem Cell Research - Bcl-2 reduced/Fas activated by SCF/KIT inhibition signaling in melanocyte SCs

Stem Cell Research - Cytokines reverse gamma-globin gene silencing in erythroid stem cells

Stem Cell Research - HSC homing is optimal when CXCR4 is incorporated in membrane lipid rafts

Stem Cell Research - Negative feedback loop controls SCF-KIT signaling pathway

Stem Cell Research - PBMCs and BM-derived HPC populations affected by acute soman poisoning

Stem Cell Research - Prominin-1/CD133 is expressed certain types of kidney cancer

Stem Cell Transplantation - Chronic GVHD risk increased in patients with HLA class I mismatched donors

Stem Cell Transplantation - High plasmacytoid dendritic cell recovery improves overall survival after ASCT

Stem Cell Transplantation - Selected cytokine elimination does not alter allogeneic hematopoietic resistance

Stem-Cell Transplantation - Novel real-time PCR assay facilitates assessment of hematopoietic chimerism

Stroke Therapy - Antibodies specific for myelin-associated glycoprotein are neuroprotective

Systemic Lupus Erythematosus - Rituximab induced remission from hypercoagulable state associated with LA

Tissue Engineering - Articular chondrocytes express phenotype in a collagen-containing sponge

Tissue Engineering - Hyaluronan gels useful for tissue engineering of aortic heart valves

Tissue Engineering - Mechanical load promotes osteoblastic stem cell proliferation in Col I matrix

Tissue Engineering - tHA ceramics support cell attachment/proliferation/differentiation

Transplant Medicine - Autoimmune hepatitis forms following orthotopic liver transplantation

Transplant Medicine - Cyclosporine A-based combo therapy ineffective in preventing bone rejection

Transplant Medicine - Cyclosporine is rescue therapy for living donor adult liver transplant patients

Transplant Medicine - Drug combination is effective in the prevention of graft rejection

Transplant Medicine - First patient receives islet transplant without long-term immune suppression

Transplant Medicine - Islet transplant completed in a patient with type 1 diabetes

Transplant Medicine - Kidney transplant recipients need to exercise, monitor diet

Tuberculosis - String test as sensitive as sputum induction for TB detection in HIV infection

Tuberculosis Vaccine - Fragmented M. tuberculosis cells increase efficacy of therapy against TB

Tuberculosis Vaccine - Plasmid DNA encoding mycobacterial hsp65 is effective treatment for TB

Tuberculosis Vaccine - Secretory protein ESAT-6 of Mycobacterium tuberculosis cloned

Tuberculosis Vaccine - Vaccination of possums with BCG reduces Mycobacterium bovis replication

Tuberculosis Vaccines - New findings in the area of tuberculosis vaccines detailed

Tuberculosis and Candida Coinfection - Candida coinfection higher in tuberculosis patients with complications

Type 1 Diabetes - First insulin-producing islet cell transplantation completed in diabetes patient

Umbilical Cord Blood Research - TGF-beta1 suppresses CTL differentiation of cord blood naive CD8+ cells

Urology - Hypoxia-inducible factor predicts the risk for bladder cancer progression

Vaccine Development - Accomplishments noted in smallpox vaccine program

Vaccine Development - Clinical holds for vaccine INDs reviewed

Vaccine Development - Proteome microarrays used to profile humoral immune response to infection

Vaccine Development - Vaccinia or BCG immunization of melanoma patients linked to better survival

Vaccine Vector - Vector with mutant neo gene selects stable clones expressing fusion protein

Variant Creutzfeldt-Jakob Disease - Model choices for variant Creutzfeldt-Jakob disease projections are problematic

Virology - MHC class molecules studied, complex with influenza virus epitopes revealed

Virology - Recent findings illuminate research in virology

West Nile Virus - Interferon can cure cells of West Nile virus replicons

Wound Healing - CE mark awarded to sell chitoskin wound pad in European Union countries

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