Myelodysplastic Syndrome

Immunobiologic therapies for myelodysplastic syndrome reviewed

Published in Immunotherapy Weekly, April 6th, 2005

An investigator reviews immunobiologic therapies for myelodysplastic syndrome in a recent issue of Best Practice and Research Clinical Haematology.

"Recent progress in understanding the pathobiology of the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) have led to the development of various immunologically oriented therapies for these diseases. The existence of elevated levels of tumor necrosis factor-alpha (TNF-alpha) in bone marrow during early stages of MIDS, and the possibility that TNF-alpha suppresses normal hematopoiesis led to studies of attempts to block the activity of TNF-alpha. An anti-TNF monoclonal antibody and an antibody comprised...

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Source: Immunotherapy Weekly (2005-04-06)

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